{"id":"W2132279425","doi":"10.1126/science.1063397","title":"Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap","year":2001,"lang":"en","type":"article","venue":"Science","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":282,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Amgen (Canada); University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"T-cell receptor; Adapter (computing); Cell biology; Biology; T cell; Integrin; Avidity; Signal transducing adaptor protein; CD8; Signal transduction; Immune system; Receptor; Immunology; Antigen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001804382,0.0003376813,0.0001900312,0.0002003662,0.0001889817,0.0004673158,0.0002025344,0.0003003144,0.001327319],"category_scores_gemma":[0.0003791707,0.0001264602,0.0001115667,0.0001018913,0.0003297865,0.0003380236,0.0004529445,0.0003947171,0.0004084732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002857805,"about_ca_system_score_gemma":0.0001254303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001764919,"about_ca_topic_score_gemma":0.0002051463,"domain_scores_codex":[0.9998019,0.00002704194,0.00001033277,0.00002468484,0.00006144199,0.00007446338],"domain_scores_gemma":[0.99984,0.00002454518,0.00005663649,0.00001317952,0.00001338854,0.00005226487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001306681,0.00001056235,0.0003031838,0.00002525769,0.000002270872,0.0001369259,0.00001016321,0.00002965657,0.9962232,0.0004909461,0.00008792056,0.002549222],"study_design_scores_gemma":[0.00007337973,0.0001965594,0.01135875,0.00001686459,0.00001662115,0.001721044,0.00005233685,0.001102085,0.9813182,0.0004781005,0.00366055,0.000005625165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934561,0.002813377,0.001470172,0.0001446817,0.00001870187,0.000007365124,0.00005866065,0.00002973585,0.002001191],"genre_scores_gemma":[0.9978796,0.00066313,0.0005350688,0.00003790895,0.00001491819,0.0000103086,0.00008750457,0.000007986404,0.0007635853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001327319,"threshold_uncertainty_score":0.004440308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01955366917939353,"score_gpt":0.2983740265492325,"score_spread":0.2788203573698389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}