{"id":"W2132329088","doi":"10.1128/aac.44.4.929-937.2000","title":"Antiviral Properties of a Series of 1,6-Naphthyridine and 7,8-Dihydroisoquinoline Derivatives Exhibiting Potent Activity against Human Cytomegalovirus","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"BioPhage Pharma (Canada)","funders":"","keywords":"Ganciclovir; Human cytomegalovirus; Foscarnet; Cidofovir; In vitro; Mechanism of action; Pharmacology; Cytotoxicity; Biology; Virology; Stereochemistry; Chemistry; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147583,0.0002964946,0.0002342207,0.0002419581,0.0001378602,0.0001693558,0.0002458718,0.0002050779,0.0007760866],"category_scores_gemma":[0.0001563154,0.0001047589,0.0001738181,0.0001317388,0.0001742482,0.0001480043,0.00009605192,0.0002865004,0.0002350805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00019526,"about_ca_system_score_gemma":0.000151892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004840726,"about_ca_topic_score_gemma":0.000942176,"domain_scores_codex":[0.999936,0.00001652323,0.000007037645,0.00001233978,0.00001442705,0.00001365272],"domain_scores_gemma":[0.9999387,0.00001234283,0.00001266788,0.000006084024,0.00001093583,0.00001922371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006995151,0.0002089247,0.0005161449,0.0001799577,0.00001731588,0.0001607701,0.00005709706,0.0009129398,0.9845545,0.0001916396,0.0001997541,0.01230137],"study_design_scores_gemma":[0.0003197303,0.009837636,0.01191064,0.0000490105,0.00008741283,0.001196272,0.00005538987,0.002089837,0.9652624,0.0001185016,0.009033731,0.00003944046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990959,0.005627343,0.0005500171,0.0000538475,0.00001994431,0.00004621387,0.0003167973,0.00003098052,0.002395666],"genre_scores_gemma":[0.9929436,0.00361496,0.001118193,0.00006466519,0.00001392595,0.00003387918,0.0007429774,0.000007284325,0.001460463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007760866,"threshold_uncertainty_score":0.002596259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01851664382589572,"score_gpt":0.2459094401740208,"score_spread":0.2273927963481251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}