{"id":"W2132367522","doi":"10.1016/j.febslet.2015.09.015","title":"STIM1 is cleaved by calpain","year":2015,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Università degli Studi di Padova; University of Alberta; Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Calpain; STIM1; ORAI1; Cell biology; Proteases; Calpastatin; Chemistry; Cytoplasm; Cleavage (geology); Endoplasmic reticulum; Apoptosis; Biophysics; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288547,0.0004438948,0.0003939087,0.0004126254,0.0003435405,0.0005519836,0.0001865985,0.0004197555,0.00294036],"category_scores_gemma":[0.0003016485,0.0001989846,0.0005346238,0.0002545534,0.0002521961,0.000359756,0.0004888563,0.0007372027,0.0009312158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005958828,"about_ca_system_score_gemma":0.0003000137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005914887,"about_ca_topic_score_gemma":0.0005544997,"domain_scores_codex":[0.9997546,0.00001814479,0.00001587817,0.00005752188,0.0000722503,0.00008170208],"domain_scores_gemma":[0.9998319,0.00001588381,0.00004904414,0.00001525846,0.00004797172,0.00003999722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002201592,0.0000146145,0.001089349,0.0001328106,0.00002354251,0.0003513529,0.0000513368,0.00004303806,0.9906327,0.000403602,0.0007194743,0.006318086],"study_design_scores_gemma":[0.00003794643,0.0001776263,0.02991128,0.00002685831,0.0000314848,0.002997792,0.00007546375,0.0009211731,0.9419765,0.0003821922,0.02344776,0.00001389964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9566926,0.02322738,0.008110088,0.001091374,0.0003001853,0.0001125194,0.00160405,0.0003990792,0.008462684],"genre_scores_gemma":[0.9748027,0.006826441,0.004049403,0.0004797926,0.0001338354,0.00008672165,0.002956318,0.00005491349,0.01060989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00294036,"threshold_uncertainty_score":0.009836495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05189569941148041,"score_gpt":0.2613078679162349,"score_spread":0.2094121685047545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}