{"id":"W2132369839","doi":"10.1124/dmd.105.007898","title":"A PHARMACOKINETIC STUDY OF DIPHENHYDRAMINE TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER IN ADULT SHEEP: POTENTIAL INVOLVEMENT OF A CARRIER-MEDIATED MECHANISM","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Diphenhydramine; Blood–brain barrier; Mechanism (biology); Pharmacokinetics; Pharmacology; Chemistry; Medicine; Central nervous system; Internal medicine; Histamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003976945,0.0002498533,0.0005823463,0.000139003,0.00008838676,0.000009223008,0.0001138452,0.00008080427,0.00006242537],"category_scores_gemma":[0.00001000422,0.0001743056,0.000136269,0.0003886029,0.0001033669,0.0001027203,0.00001912105,0.0001759176,5.972444e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001036445,"about_ca_system_score_gemma":0.00003992241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001694689,"about_ca_topic_score_gemma":0.00133203,"domain_scores_codex":[0.997999,0.00009237146,0.0007174957,0.0003364734,0.0005446557,0.0003099793],"domain_scores_gemma":[0.9992615,0.00003279073,0.0001921241,0.000257964,0.0001524179,0.0001032183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001938138,0.005404156,0.01124834,0.0007173237,0.0003581191,0.000261052,0.01704109,0.0002454984,0.9571675,0.004377351,0.00004349244,0.001197943],"study_design_scores_gemma":[0.02761714,0.0005044452,0.6929865,0.0003690171,0.002709745,0.00002269346,0.01174178,0.001001105,0.2611069,0.001273534,0.0001873977,0.0004796563],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964776,0.0007946852,0.0003611877,0.0002689906,0.0001667419,0.001274961,0.0005548779,0.0000258447,0.00007510158],"genre_scores_gemma":[0.9987085,0.0000995981,0.00007540063,0.0001661947,0.0001098522,0.0001110731,0.0005365108,0.0000270764,0.000165782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6960605,"threshold_uncertainty_score":0.7107977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003898386035375482,"score_gpt":0.2283425256333545,"score_spread":0.224444139597979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}