{"id":"W2132369839","doi":"10.1124/dmd.105.007898","title":"A PHARMACOKINETIC STUDY OF DIPHENHYDRAMINE TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER IN ADULT SHEEP: POTENTIAL INVOLVEMENT OF A CARRIER-MEDIATED MECHANISM","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Diphenhydramine; Blood–brain barrier; Mechanism (biology); Pharmacokinetics; Pharmacology; Chemistry; Medicine; Central nervous system; Internal medicine; Histamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002731638,0.0002441166,0.0004240034,0.0001519803,0.0001643468,0.0002400024,0.0001760517,0.0003877682,0.0007099474],"category_scores_gemma":[0.0007045671,0.000154835,0.0001525205,0.0001128321,0.0004735561,0.0004245957,0.0001021746,0.0005601326,0.0002141485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000148119,"about_ca_system_score_gemma":0.0001710932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001053452,"about_ca_topic_score_gemma":0.0008981015,"domain_scores_codex":[0.9999319,0.00001836451,0.000005201658,0.00002192904,0.00001164227,0.0000108369],"domain_scores_gemma":[0.9996525,0.0001449774,0.00006226868,0.0000377033,0.00003146256,0.00007100694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009741672,0.0002935843,0.01983537,0.0003048895,0.00004329212,0.002162006,0.001017821,0.0003890817,0.9397365,0.0005750256,0.0002689799,0.02563172],"study_design_scores_gemma":[0.0005544898,0.08701934,0.3022869,0.00007240402,0.0005182032,0.01494492,0.001210701,0.01312821,0.5674512,0.0008383697,0.01188939,0.00008584007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977494,0.000510074,0.001372565,0.00003774658,0.000006630744,0.00001520724,0.00005998791,0.00001309366,0.0002353171],"genre_scores_gemma":[0.9973968,0.0004936297,0.001287245,0.00003156825,0.00001449454,0.00002776642,0.0001181076,0.000008906806,0.0006213697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001053452,"threshold_uncertainty_score":0.002375007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003898386035375482,"score_gpt":0.2283425256333545,"score_spread":0.224444139597979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}