{"id":"W2132422168","doi":"10.1016/s1471-4914(03)00007-8","title":"Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease","year":2003,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":162,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas Mental Health University Institute; Douglas College","funders":"","keywords":"Pathogenesis; Apolipoprotein E; Probucol; Dementia; Disease; Apolipoprotein B; Medicine; Cholesterol; Alzheimer's disease; Vascular dementia; Metabolic syndrome; Internal medicine; Lipid metabolism; Endocrinology; Bioinformatics; Biology; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003618647,0.0006251879,0.002352464,0.0009901738,0.00003600233,0.00001065788,0.0001254397,0.0001774567,0.0000590038],"category_scores_gemma":[0.00005413351,0.0003385278,0.0002701789,0.0008346074,0.0005045506,0.00003451909,0.00004089029,0.0002279363,0.000002592675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007473052,"about_ca_system_score_gemma":0.0001949439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002615471,"about_ca_topic_score_gemma":0.00002363077,"domain_scores_codex":[0.9968893,0.0006536888,0.0007468114,0.0006369451,0.0006182326,0.0004550291],"domain_scores_gemma":[0.9984021,0.00009849201,0.0002113584,0.0007675228,0.00003490932,0.0004856401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009792966,0.0007251718,0.0004358877,0.001391968,0.00298666,0.002364046,0.0001927682,7.436401e-8,0.000003460778,0.0001086838,0.00001719466,0.9916762],"study_design_scores_gemma":[0.04541055,0.007131508,0.1426642,0.04528815,0.1319697,0.001506136,0.0004808001,0.0000319092,0.00005395156,0.0005080797,0.6228156,0.002139321],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002309073,0.9953247,0.000002367377,0.0003635841,0.00003112439,0.001572922,0.00008260894,0.000009843429,0.000303738],"genre_scores_gemma":[0.007708918,0.9909239,0.00008581289,0.000118534,0.00007143166,0.0006763846,0.0003249828,0.00006361776,0.00002635663],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9895368,"threshold_uncertainty_score":0.9999067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06871606587893399,"score_gpt":0.3804448953974548,"score_spread":0.3117288295185208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}