{"id":"W2132466276","doi":"10.1111/j.1525-139x.2011.00826.x","title":"How to Optimize Drug Delivery in Renal Replacement Therapy","year":2011,"lang":"en","type":"review","venue":"Seminars in Dialysis","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Medicine; Dosing; Renal replacement therapy; Pharmacokinetics; Drug; Extracorporeal; Intensive care medicine; Acute kidney injury; Therapeutic index; Therapeutic drug monitoring; Clearance; Dialysis; Renal function; Pharmacology; Adverse effect; Internal medicine; Urology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006955318,0.0004985351,0.002178388,0.001024315,0.00002650537,0.00004164092,0.0003428725,0.0002548482,0.0002557166],"category_scores_gemma":[0.0001219613,0.0004027115,0.0005940931,0.001125922,0.000050751,0.0000360229,0.000176019,0.0005815508,0.00005983625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003102738,"about_ca_system_score_gemma":0.0002004456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001266122,"about_ca_topic_score_gemma":0.00004979298,"domain_scores_codex":[0.9975216,0.0001719264,0.0007509396,0.0007215128,0.0003103952,0.0005236164],"domain_scores_gemma":[0.9985139,0.0001603027,0.0002461222,0.0007741693,0.00006314219,0.0002423042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002197992,0.0003774042,0.0001692491,0.001369902,0.0003071128,0.000191389,0.0004840766,0.00001296201,0.00001033128,0.000007956079,0.008094158,0.9887556],"study_design_scores_gemma":[0.001227518,0.0001598663,0.00002148376,0.01493487,0.0008828845,0.0000138216,0.00006275231,0.00003975443,0.0000821806,0.000008239634,0.9821496,0.0004170056],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001653534,0.9951472,0.00002581068,0.000306118,0.000216217,0.001308342,0.00001754267,0.00002396465,0.001301279],"genre_scores_gemma":[0.0002407342,0.9926229,0.002808062,0.0002397414,0.0002274606,0.00006988754,0.0001296554,0.00008270531,0.00357893],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9883386,"threshold_uncertainty_score":0.9998425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04664045454913952,"score_gpt":0.3333145254401761,"score_spread":0.2866740708910366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}