{"id":"W2132487225","doi":"10.2174/187152012798764741","title":"Impact of Oncogenic Protein Tyrosine Phosphatases in Cancer","year":2012,"lang":"en","type":"review","venue":"Anti-Cancer Agents in Medicinal Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Protein tyrosine phosphatase; Receptor tyrosine kinase; Phosphorylation; Phosphatase; Carcinogenesis; G protein-coupled receptor; Biology; Receptor Protein-Tyrosine Kinases; Tyrosine phosphorylation; Protein phosphorylation; Cancer; Proto-oncogene tyrosine-protein kinase Src; Kinase; Signal transduction; Cancer research; Dual-specificity phosphatase; Tyrosine kinase; PTPN11; Receptor; Tyrosine; Cell biology; Biochemistry; Protein kinase A; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003977059,0.0008034263,0.00188428,0.0001210694,0.00003173142,0.0000126962,0.000845445,0.0006857663,0.0008973674],"category_scores_gemma":[0.0001596206,0.0006760874,0.0005503777,0.0005758972,0.0002687217,0.00001446576,0.0003427657,0.0006263906,0.000007579089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004434708,"about_ca_system_score_gemma":0.001376503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002015109,"about_ca_topic_score_gemma":0.0000599444,"domain_scores_codex":[0.9966006,0.00009971121,0.001174032,0.0008548009,0.0004523247,0.0008185101],"domain_scores_gemma":[0.9980029,0.00002195452,0.0008046528,0.0008584043,0.00009140091,0.0002206422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003213101,0.001280348,0.01702138,0.0490092,0.001194615,0.0001265174,0.00004644756,0.00005113793,0.03890279,0.000005807032,0.004191181,0.8878493],"study_design_scores_gemma":[0.002225984,0.000241821,0.001528863,0.0318441,0.0008457619,0.00004773023,0.00001419022,0.000003477374,0.5031188,0.000005803489,0.4587689,0.001354561],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0373917,0.9596263,0.000003635232,0.000009563908,0.0001637379,0.001026333,0.001689667,0.000010141,0.0000789097],"genre_scores_gemma":[0.03342828,0.962597,0.00005778342,0.00003207662,0.0007131287,0.0009807614,0.001748418,0.000108625,0.0003339107],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8864947,"threshold_uncertainty_score":0.9995691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06572485144887852,"score_gpt":0.4109783406509359,"score_spread":0.3452534892020574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}