{"id":"W2132506678","doi":"10.1128/aac.01536-13","title":"Role of the K101E Substitution in HIV-1 Reverse Transcriptase in Resistance to Rilpivirine and Other Nonnucleoside Reverse Transcriptase Inhibitors","year":2013,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Institute for Health and Care Research","keywords":"Rilpivirine; Reverse transcriptase; Etravirine; Nevirapine; Virology; Efavirenz; Reverse-transcriptase inhibitor; Biology; Emtricitabine; Viral replication; Chemistry; Viral load; Human immunodeficiency virus (HIV); Genetics; Virus; RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002338253,0.000386511,0.000423393,0.0001431524,0.0001588721,0.0004754109,0.0003594115,0.0004357184,0.001470253],"category_scores_gemma":[0.0004094004,0.0001515024,0.0002748519,0.000173806,0.0002981798,0.0002790334,0.0003110553,0.000412611,0.0005474091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003264797,"about_ca_system_score_gemma":0.0002243051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006768703,"about_ca_topic_score_gemma":0.0007211606,"domain_scores_codex":[0.9996339,0.00009107604,0.00006500951,0.00005768858,0.0001114991,0.00004076293],"domain_scores_gemma":[0.9998079,0.00006127681,0.00005458546,0.0000234908,0.00001636312,0.00003643538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002942504,0.0001389882,0.001285234,0.0000494105,0.00002205557,0.0003620473,0.00001893104,0.0003183646,0.9941515,0.0001766507,0.00004230816,0.003140299],"study_design_scores_gemma":[0.00008111069,0.0009214535,0.008338114,0.00001767478,0.00003674015,0.002136759,0.00009787988,0.003171753,0.9827827,0.0001104124,0.002282555,0.00002284888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974547,0.0007156052,0.0007170188,0.00009017096,0.00002464545,0.00002234448,0.0001234414,0.00001761949,0.0008344586],"genre_scores_gemma":[0.9979125,0.0002920389,0.0008318299,0.00004551632,0.000004835684,0.000011051,0.0001928717,0.00001286526,0.0006963791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001470253,"threshold_uncertainty_score":0.004918456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007245197270705556,"score_gpt":0.216341394661178,"score_spread":0.2090961973904724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}