{"id":"W2132513517","doi":"10.1128/jvi.00493-12","title":"Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Capsid; Biology; Infectivity; Binding site; Virus; In vitro; Viral replication; Virology; Molecular biology; Biochemistry; Biophysics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508058,0.0004159352,0.0004204309,0.0002407514,0.000157804,0.0003378159,0.0002935933,0.0002457687,0.0007975142],"category_scores_gemma":[0.0002711867,0.0001785663,0.0001879622,0.0001581129,0.0001953412,0.0001424726,0.0001521166,0.0004756511,0.0001449189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003248159,"about_ca_system_score_gemma":0.0002705676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001539532,"about_ca_topic_score_gemma":0.003651003,"domain_scores_codex":[0.9998603,0.00002815838,0.0000101813,0.0000208805,0.0000377675,0.00004278749],"domain_scores_gemma":[0.9998847,0.00003350768,0.00002569775,0.000007760312,0.00001613416,0.00003210308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008277561,0.0003333647,0.0007953179,0.00008296387,0.00002846978,0.00006454722,0.00002867264,0.0004028179,0.9906983,0.0001254459,0.00008813451,0.006524228],"study_design_scores_gemma":[0.0002802756,0.006578392,0.01736468,0.00001552097,0.0001305329,0.0008449638,0.0000557908,0.003065546,0.9683759,0.00005491307,0.003211562,0.00002191005],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957532,0.002003678,0.00040547,0.00003600388,0.00001116852,0.00004070113,0.0001177091,0.0000288508,0.001603377],"genre_scores_gemma":[0.9954699,0.00152352,0.001304489,0.00005342664,0.000009881463,0.00003865065,0.0003702524,0.00001006875,0.001219842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001539532,"threshold_uncertainty_score":0.003061116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008650515691952451,"score_gpt":0.25233980221388,"score_spread":0.2436892865219275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}