{"id":"W2132513517","doi":"10.1128/jvi.00493-12","title":"Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"National Institute of General Medical Sciences; National Institutes of Health","keywords":"Capsid; Biology; Infectivity; Binding site; Virus; In vitro; Viral replication; Virology; Molecular biology; Biochemistry; Biophysics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001098931,0.0001835034,0.000431358,0.00008991878,0.0002254302,0.000008354196,0.0004846195,0.000156257,0.00006199972],"category_scores_gemma":[0.0002277067,0.00007299522,0.0002470398,0.0001036596,0.001082677,0.0001006208,0.0001810212,0.0007031432,0.00008156496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000457387,"about_ca_system_score_gemma":0.0001399598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001475089,"about_ca_topic_score_gemma":0.0001572541,"domain_scores_codex":[0.9972866,0.001568759,0.0004753963,0.0001084314,0.0001369839,0.0004238964],"domain_scores_gemma":[0.9980816,0.0007043766,0.0007425096,0.000347311,0.0000832262,0.00004102252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009931767,0.0004364652,0.05134727,0.00004925349,0.0005489157,0.00005545644,0.002927618,0.000006261635,0.9410717,0.0004601052,0.001343782,0.0007599704],"study_design_scores_gemma":[0.005257065,0.002806475,0.2808902,0.0001551659,0.0003137497,0.002324359,0.0007796693,0.000002818857,0.7012076,0.0006422143,0.005464813,0.0001558376],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994046,0.003200901,0.00004510983,0.001418722,0.0006200979,0.0004757881,0.00005649206,0.000003139174,0.0001337846],"genre_scores_gemma":[0.9992517,0.00002634201,0.00005455313,0.00010405,0.0001413011,0.00002211284,0.000006522861,0.00001167149,0.0003817219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2398641,"threshold_uncertainty_score":0.3989167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008650515691952451,"score_gpt":0.25233980221388,"score_spread":0.2436892865219275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}