{"id":"W2132545630","doi":"10.1200/jco.2007.11.3357","title":"Randomized, Controlled Trial of Irinotecan Plus Infusional, Bolus, or Oral Fluoropyrimidines in First-Line Treatment of Metastatic Colorectal Cancer: Results From the BICC-C Study","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":857,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lakeridge Health","funders":"","keywords":"FOLFIRI; Medicine; Irinotecan; Bevacizumab; Internal medicine; Clinical endpoint; Colorectal cancer; Gastroenterology; Fluorouracil; Capecitabine; Surgery; Oncology; Randomized controlled trial; Chemotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002459605,0.001618722,0.004187194,0.0004535219,0.0005966239,0.001339072,0.0009988016,0.001949591,0.008072553],"category_scores_gemma":[0.002945481,0.0006761834,0.002122084,0.000513333,0.001040119,0.0007448921,0.0003722186,0.003070832,0.001089935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001002476,"about_ca_system_score_gemma":0.002186356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002123366,"about_ca_topic_score_gemma":0.005035304,"domain_scores_codex":[0.998915,0.0006331677,0.00007823303,0.0001732147,0.00008646874,0.0001139875],"domain_scores_gemma":[0.9982435,0.0005313418,0.0004320938,0.0001198421,0.0001367921,0.0005364745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9907767,0.002543503,0.000254455,0.0003692528,0.0006569097,0.00001240374,0.00001526644,0.0001085233,0.0006166392,0.0000311507,0.0004299567,0.004185163],"study_design_scores_gemma":[0.984647,0.01402059,0.0005644796,0.00001560377,0.0003070354,0.000008207319,0.000004436752,0.0001081522,0.00008173774,0.0000215312,0.0002161193,0.000005105005],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716291,0.01205565,0.0007922195,0.0009885769,0.001368591,0.007885664,0.00237631,0.0001754244,0.002728297],"genre_scores_gemma":[0.9768146,0.00590858,0.001763787,0.001827499,0.0009022342,0.006690582,0.002546237,0.00003912845,0.003507487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008072553,"threshold_uncertainty_score":0.02700537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1741197648038616,"score_gpt":0.4876139936765206,"score_spread":0.3134942288726591,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}