{"id":"W2132546867","doi":"10.1038/ng.2529","title":"The genetic landscape of high-risk neuroblastoma","year":2013,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":1219,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; National Human Genome Research Institute; National Institute on Minority Health and Health Disparities; Canadian Institutes of Health Research; National Institutes of Health","keywords":"ATRX; Biology; Neuroblastoma RAS viral oncogene homolog; PTPN11; Neuroblastoma; Germline mutation; Germline; Exome sequencing; CHEK2; Genetics; Somatic cell; Cancer research; Mutation; Exome; Gene; KRAS","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002881937,0.0002309509,0.0002771819,0.001012964,0.0004973285,0.0007023364,0.0004430694,0.0006459038,0.00324228],"category_scores_gemma":[0.002171354,0.0001594577,0.0001861276,0.001103213,0.0004338297,0.0004484081,0.0005535993,0.0005451415,0.0002553283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000432258,"about_ca_system_score_gemma":0.0004590744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003782628,"about_ca_topic_score_gemma":0.003994302,"domain_scores_codex":[0.9995204,0.0001475805,0.00003265743,0.00009762342,0.0001219948,0.00007977036],"domain_scores_gemma":[0.9993912,0.0002260837,0.000177943,0.00003150589,0.00006878533,0.0001044664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007824718,0.00009545189,0.8957937,0.0001047935,0.0002543767,0.01046131,0.0007791095,0.001452011,0.03050644,0.007062417,0.002508861,0.05019905],"study_design_scores_gemma":[0.00003413516,0.0001753307,0.9441224,0.0001487467,0.0003466511,0.02608582,0.001678085,0.001650979,0.004285083,0.01487067,0.006554089,0.00004794243],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871071,0.003664813,0.0005087141,0.002602452,0.00003054405,0.000008902688,0.0003880947,0.00001881386,0.005670501],"genre_scores_gemma":[0.9976615,0.001354927,0.0002749702,0.0001229764,0.00004307994,0.000002936468,0.0001521507,0.000009833462,0.0003777337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003782628,"threshold_uncertainty_score":0.0108465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005299584076040456,"score_gpt":0.2492781974386105,"score_spread":0.2439786133625701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}