{"id":"W2132555177","doi":"10.1101/gad.198200.112","title":"D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function","year":2012,"lang":"en","type":"article","venue":"Genes & Development","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":297,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Biology; Mutant; Endoplasmic reticulum; Isocitrate dehydrogenase; IDH1; Cell biology; Subcellular localization; Molecular biology; Transcription factor; Intracellular; Biochemistry; Gene; Enzyme; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002754429,0.0001953314,0.0001451245,0.00003496709,0.0001516702,0.00003440644,0.00006777854,0.0001021862,0.00005797527],"category_scores_gemma":[0.00001399054,0.000176539,0.00003083265,0.00007198762,0.00002551666,0.00001274764,0.00007743026,0.00003280148,0.00002430696],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003617555,"about_ca_system_score_gemma":0.0001188097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001304483,"about_ca_topic_score_gemma":0.00002035938,"domain_scores_codex":[0.9988838,0.00004260783,0.0002288891,0.0003372048,0.0001756245,0.0003318889],"domain_scores_gemma":[0.9995105,0.000003380566,0.00007831059,0.0001973085,0.00007059452,0.0001399556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001217947,0.00004977791,0.000363794,0.00002563126,0.00007103049,1.529802e-7,0.000233225,0.000006457924,0.9578841,0.00001093804,0.005651722,0.03558133],"study_design_scores_gemma":[0.0002669439,0.00002726129,0.00304598,0.000003829731,0.00002126075,0.000006422681,0.00004195601,0.000006734366,0.5136365,0.000001804529,0.4827941,0.0001471084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758446,0.02111734,0.0007446527,0.0001775446,0.001532242,0.0003980814,0.00001448478,0.00001933088,0.0001516725],"genre_scores_gemma":[0.9917688,0.00334357,0.001174126,0.0005408269,0.001225533,0.0001510888,0.000429193,0.00002836035,0.001338542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4771424,"threshold_uncertainty_score":0.719905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007511285085852419,"score_gpt":0.2113291734463008,"score_spread":0.2038178883604484,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}