{"id":"W2132603119","doi":"10.1124/dmd.104.001149","title":"THE ROLES OF TRANSPORTERS AND ENZYMES IN HEPATIC DRUG PROCESSING","year":2004,"lang":"en","type":"review","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Transporter; Drug; Drug metabolism; Enzyme; Pharmacology; Chemistry; Biochemistry; Biology; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003421569,0.0003054956,0.00123417,0.0001762463,0.000118508,0.0000316183,0.00007463653,0.0001181252,0.000002889667],"category_scores_gemma":[0.000004877457,0.0001801499,0.0001892114,0.0002282981,0.0001651193,0.0001073853,0.000008175245,0.0002305433,5.501416e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000209324,"about_ca_system_score_gemma":0.0001684683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004136333,"about_ca_topic_score_gemma":0.0001849584,"domain_scores_codex":[0.998584,0.0000602008,0.0005987913,0.0003042748,0.0002335445,0.0002192089],"domain_scores_gemma":[0.9994261,0.0000461046,0.0002304904,0.0001684244,0.00003385537,0.00009501767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008029416,0.0001134547,0.00004181768,0.04616661,0.00006680552,0.0000353338,0.002121332,4.950959e-7,0.00001558175,0.003735791,0.00000513365,0.9476174],"study_design_scores_gemma":[0.00672171,0.00009997869,0.009511104,0.2084704,0.01765299,0.0002388036,0.003966771,0.0000522743,0.001106547,0.003947191,0.7464843,0.001747909],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004326211,0.9945386,0.00007617971,0.0001025391,0.00009744064,0.0006956225,0.00004028816,0.00001980051,0.0001032851],"genre_scores_gemma":[0.03050612,0.9688478,0.0001447794,0.00002021927,0.00006328491,0.00006159626,0.0001697857,0.00003248476,0.0001539661],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9458694,"threshold_uncertainty_score":0.7346299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008756476596063524,"score_gpt":0.2633485320322888,"score_spread":0.2545920554362252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}