{"id":"W2132603400","doi":"10.1186/1897-4287-7-14","title":"Penetrance of colorectal cancer among MLH1/MSH2 carriers participating in the colorectal cancer familial registry in Ontario","year":2009,"lang":"en","type":"article","venue":"Hereditary Cancer in Clinical Practice","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; Mount Sinai Hospital; Cancer Care Ontario; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; National Institutes of Health; National Cancer Institute; Cancer Care Ontario","keywords":"MLH1; Lynch syndrome; Medicine; MSH2; Colorectal cancer; Penetrance; Population; Cancer registry; Oncology; Cancer; DNA mismatch repair; Internal medicine; Gynecology; Genetics; Biology; Environmental health; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00312035,0.0004998581,0.001256865,0.0001931256,0.00008411259,0.00003231331,0.0006171599,0.0006297511,0.001060078],"category_scores_gemma":[0.004239257,0.0004288695,0.0002703888,0.001148261,0.000658826,0.0004887055,0.00009055214,0.003520056,0.000004214029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002252442,"about_ca_system_score_gemma":0.00407787,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.4331823,"about_ca_topic_score_gemma":0.8751817,"domain_scores_codex":[0.9934353,0.000900626,0.00240432,0.001074113,0.001183318,0.001002304],"domain_scores_gemma":[0.9944903,0.003470511,0.0008804242,0.0005701716,0.0003123249,0.0002762231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006840303,0.0008921431,0.9662265,0.00009975079,0.0001067152,0.0006438724,0.00480874,0.005300646,0.0008040975,0.00001170249,0.002007588,0.01225791],"study_design_scores_gemma":[0.004574468,0.001375196,0.9855191,0.0009022564,0.0002343308,0.00003962316,0.002302574,0.00105705,0.0009222119,0.00008148199,0.002558504,0.0004331687],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814935,0.003674808,0.000002711005,0.0044469,0.002781213,0.001567086,0.00009094967,0.00003313605,0.005909707],"genre_scores_gemma":[0.9924497,0.001726643,0.0006018643,0.002787226,0.0008304747,0.001437551,0.00001306575,0.00004891387,0.0001045797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4419994,"threshold_uncertainty_score":0.9998531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0689670318470987,"score_gpt":0.4119250256052817,"score_spread":0.342957993758183,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}