{"id":"W2132609557","doi":"10.1534/genetics.112.141739","title":"The Importance of Conserved Features of Yeast Actin-Binding Protein 1 (Abp1p): The Conditional Nature of Essentiality","year":2012,"lang":"en","type":"article","venue":"Genetics","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Biology; Conserved sequence; Genetics; SH3 domain; Saccharomyces cerevisiae; Homology (biology); Sequence motif; Phosphorylation; Mutant; Peptide sequence; Serine; Protein family; Phenotype; Protein domain; Sequence alignment; Amino acid; Biochemistry; Yeast; Gene; Proto-oncogene tyrosine-protein kinase Src","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002345674,0.0000744722,0.00009141576,0.00001148672,0.00007590754,0.000005899337,0.0001812562,0.0001159076,0.00002396588],"category_scores_gemma":[0.000089905,0.00004890824,0.00009721024,0.00005498125,0.0001240518,0.000002231213,0.00008035637,0.0001290653,5.735145e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004250317,"about_ca_system_score_gemma":0.0000615649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006842935,"about_ca_topic_score_gemma":0.00004374157,"domain_scores_codex":[0.9993746,0.00005600707,0.0002179539,0.0000897397,0.0001335789,0.0001280716],"domain_scores_gemma":[0.9992138,0.0000241761,0.0002705495,0.0003160542,0.0001484425,0.00002698838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003073818,0.00005196913,0.001959398,0.00001919928,0.00007070984,7.171855e-8,0.00003172671,0.000004266877,0.9934924,0.002932305,0.001300328,0.0001068724],"study_design_scores_gemma":[0.0001194724,0.00004920447,0.006614067,0.00001056336,0.0000233899,0.00000692135,0.0001830195,0.00001027909,0.9796938,0.0001997434,0.01303814,0.00005144239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996651,0.002105787,0.0002030363,0.0001756228,0.0001977569,0.0001762441,0.0001338454,0.000001384142,0.0003553141],"genre_scores_gemma":[0.9990003,0.00009940097,0.0002557266,0.0000290207,0.0001120825,0.000009981372,0.0000920478,0.000008418292,0.0003930868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01379865,"threshold_uncertainty_score":0.199442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024291351524275,"score_gpt":0.2670796764666449,"score_spread":0.2568367629514021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}