{"id":"W2132620877","doi":"10.1124/jpet.112.199661","title":"Catharanthine Dilates Small Mesenteric Arteries and Decreases Heart Rate and Cardiac Contractility by Inhibition of Voltage-Operated Calcium Channels on Vascular Smooth Muscle Cells and Cardiomyocytes","year":2013,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Plant Biotechnology Institute; University of Saskatchewan; Heart and Stroke Foundation; University of Toronto; University Health Network; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Contractility; Mesenteric arteries; Vascular smooth muscle; Internal medicine; Cardiology; Calcium; Myocyte; Medicine; Cardiac muscle; Chemistry; Smooth muscle; Artery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546268,0.0001425865,0.0002588659,0.0000366443,0.00007762845,0.00002291876,0.00002402968,0.0001020963,0.00001489577],"category_scores_gemma":[0.000001718232,0.0001171103,0.00005332598,0.00002568578,0.0002281147,0.00002377214,0.00001893773,0.00007996787,1.475564e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007008228,"about_ca_system_score_gemma":0.00001515598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002796368,"about_ca_topic_score_gemma":4.338387e-7,"domain_scores_codex":[0.9993504,0.0000957114,0.0002280723,0.0001470126,0.00005910961,0.0001197121],"domain_scores_gemma":[0.9996591,0.00002335179,0.0001173303,0.00004271995,0.0000811373,0.00007636541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003371814,0.0001137493,0.001182657,0.0000228309,0.0001756671,0.000001986262,0.0003000834,0.000006634355,0.9972685,0.000001502838,0.0001691015,0.0004201183],"study_design_scores_gemma":[0.001353328,0.0007184596,0.01751799,0.00001369164,0.0001046291,0.00001023727,0.0004016725,0.00008427803,0.9772319,0.0000131779,0.002442628,0.000108043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842943,0.01505376,0.00005980104,0.0001809942,0.0002084817,0.0001763102,0.00002035731,0.000002720828,0.000003274316],"genre_scores_gemma":[0.9958766,0.00356017,0.00002957316,0.0003810783,0.0000960257,0.000007839861,0.0000234624,0.00001033789,0.00001496023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02003662,"threshold_uncertainty_score":0.4775619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275006671775274,"score_gpt":0.2623642733814918,"score_spread":0.2496142066637391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}