{"id":"W2132628497","doi":"10.1093/jnci/djp334","title":"A Perspective on Challenges and Issues in Biomarker Development and Drug and Biomarker Codevelopment","year":2009,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute","keywords":"Biomarker; Drug development; Food and drug administration; Biomarker discovery; Medicine; Risk analysis (engineering); Drug; Computer science; Computational biology; Biology; Pharmacology; Proteomics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1486722,0.002432935,0.00341962,0.00408867,0.009427798,0.02139064,0.009046215,0.0545464,0.009681726],"category_scores_gemma":[0.08401275,0.00180526,0.003802555,0.003485877,0.02452803,0.0336637,0.01227418,0.04908952,0.002483489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01277757,"about_ca_system_score_gemma":0.04646776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008382423,"about_ca_topic_score_gemma":0.01347408,"domain_scores_codex":[0.9322708,0.04106323,0.004154371,0.004029151,0.01418758,0.004294946],"domain_scores_gemma":[0.8140931,0.1193694,0.004915577,0.004231913,0.033815,0.02357506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003622849,0.0007798815,0.001755492,0.002908026,0.0001423048,0.002613364,0.005601853,0.002601258,0.001427261,0.2410185,0.5506352,0.1901544],"study_design_scores_gemma":[0.0001642103,0.0005962934,0.001124155,0.002691369,0.00006040185,0.002045673,0.01063993,0.002014007,0.000541734,0.2116082,0.7682273,0.0002867947],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003209951,0.03384796,0.003379947,0.9540939,0.006321616,0.00003167643,0.00002083671,0.00003447644,0.001948648],"genre_scores_gemma":[0.03745062,0.1356216,0.05067887,0.7203541,0.0435379,0.0005516032,0.0001524806,0.0001862347,0.01146664],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1486722,"threshold_uncertainty_score":0.786263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.138473225469016,"score_gpt":0.4302700547783281,"score_spread":0.2917968293093121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}