{"id":"W2132640570","doi":"10.1128/iai.69.5.3143-3149.2001","title":"Activation of Extracellular Signal-Related Protein Kinases 1 and 2 of the Mitogen-Activated Protein Kinase Family by Lipopolysaccharide Requires Plasma in Neutrophils from Adults and Newborns","year":2001,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Grace (Canada); Izaak Walton Killam Health Centre; Dalhousie University","funders":"Medical Research Council","keywords":"MAPK/ERK pathway; Lipopolysaccharide; Kinase; Respiratory burst; N-Formylmethionine leucyl-phenylalanine; Protein kinase A; Mitogen-activated protein kinase; Biology; Extracellular; Signal transduction; Molecular biology; Cell biology; Immunology; Neutrophile; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002367783,0.0003286623,0.0003078417,0.0001864553,0.000121006,0.0002800133,0.0002157311,0.0003002099,0.0006467177],"category_scores_gemma":[0.0004298488,0.0001828686,0.0002312411,0.0001390924,0.0002292598,0.0002664748,0.0002590943,0.0004019364,0.0002470006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002104719,"about_ca_system_score_gemma":0.0001862828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002646476,"about_ca_topic_score_gemma":0.0002531779,"domain_scores_codex":[0.9997243,0.00006386603,0.00003914155,0.00004920944,0.00007700349,0.00004653425],"domain_scores_gemma":[0.999799,0.00003194519,0.00007407255,0.0000185317,0.00002190025,0.00005461278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001007122,0.00004572188,0.0019359,0.00009241378,0.000006929672,0.0003523813,0.00009284487,0.00005445211,0.9929144,0.0001125704,0.00005732206,0.003327806],"study_design_scores_gemma":[0.0001072226,0.001463906,0.1850485,0.00004481321,0.00004556304,0.005215545,0.0002658557,0.001425947,0.8021922,0.0002571373,0.003907453,0.00002598977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928227,0.004412618,0.001759573,0.0001000785,0.00001980733,0.00004148017,0.0002515675,0.00002613334,0.0005661063],"genre_scores_gemma":[0.9928339,0.002446148,0.002631345,0.00008594972,0.00001788834,0.000170518,0.0008582984,0.000007855987,0.0009480974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006467177,"threshold_uncertainty_score":0.00216347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100362333970932,"score_gpt":0.2100250417534457,"score_spread":0.1990214184137364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}