{"id":"W2132683766","doi":"10.1099/mic.0.2008/019455-0","title":"Additive attenuation of virulence and cariogenic potential of Streptococcus mutans by simultaneous inactivation of the ComCDE quorum-sensing system and HK/RR11 two-component regulatory system","year":2008,"lang":"en","type":"article","venue":"Microbiology","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"University of Toronto; Canadian Institutes of Health Research; Dalhousie University; University of Manitoba","keywords":"Virulence; Streptococcus mutans; Biofilm; Quorum sensing; Microbiology; Mutant; Biology; Bacteriocin; Signal transduction; Genetics; Gene; Bacteria; Antimicrobial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002665493,0.0006495886,0.0004284833,0.0003397694,0.00009686338,0.0003750742,0.0002871529,0.0002679412,0.000718348],"category_scores_gemma":[0.0002805093,0.0002158716,0.0003386787,0.0001407671,0.0002558881,0.0001939361,0.000556707,0.0004999478,0.0001423372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002303824,"about_ca_system_score_gemma":0.0003023049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000526063,"about_ca_topic_score_gemma":0.0005905734,"domain_scores_codex":[0.9994683,0.0001047276,0.00006438053,0.00006300417,0.0001916249,0.0001080873],"domain_scores_gemma":[0.9996698,0.00007333323,0.00008632299,0.00005346591,0.0000433247,0.00007381202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001920526,0.00008751549,0.0005437456,0.00002890998,0.00001461578,0.00003689513,0.00001418243,0.0001120451,0.9977471,0.00006341992,0.00000692186,0.001152523],"study_design_scores_gemma":[0.00001919129,0.001095289,0.005600615,0.000005347139,0.00006804331,0.0001981385,0.00004195198,0.002074187,0.9903079,0.00003618357,0.0005452799,0.000007969386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983034,0.0002345826,0.001039712,0.00001719,0.00000803888,0.00001245034,0.00003537165,0.00002114532,0.0003279341],"genre_scores_gemma":[0.9985916,0.0001176605,0.0006737828,0.00001168124,0.000003737138,0.00001453789,0.00007477435,0.000006753164,0.000505537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000718348,"threshold_uncertainty_score":0.00240314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006313538827166016,"score_gpt":0.2131211123704135,"score_spread":0.2068075735432474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}