{"id":"W2132683766","doi":"10.1099/mic.0.2008/019455-0","title":"Additive attenuation of virulence and cariogenic potential of Streptococcus mutans by simultaneous inactivation of the ComCDE quorum-sensing system and HK/RR11 two-component regulatory system","year":2008,"lang":"en","type":"article","venue":"Microbiology","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"University of Toronto; Canadian Institutes of Health Research; Dalhousie University; University of Manitoba","keywords":"Virulence; Streptococcus mutans; Biofilm; Quorum sensing; Microbiology; Mutant; Biology; Bacteriocin; Signal transduction; Genetics; Gene; Bacteria; Antimicrobial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006819946,0.0001221621,0.0003709271,0.00007141082,0.00009385397,0.00000151274,0.00003211424,0.0001067527,0.000003482365],"category_scores_gemma":[0.00003093151,0.00008996102,0.00005928958,0.0001215839,0.0003707133,0.00002415942,0.00004004514,0.00007654672,5.815287e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001360961,"about_ca_system_score_gemma":0.00004798227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008253097,"about_ca_topic_score_gemma":0.00002522262,"domain_scores_codex":[0.9991226,0.0001281207,0.000374635,0.0002020389,0.00005645404,0.0001162031],"domain_scores_gemma":[0.999065,0.0001343324,0.0003592188,0.0001930843,0.0002180033,0.00003030345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000116041,0.00007869162,0.03163625,0.0001639781,0.0001762592,0.00001021681,0.000212112,0.00006706958,0.9665229,0.00005769539,0.00002201163,0.0009368071],"study_design_scores_gemma":[0.002727645,0.0005566995,0.08435398,0.0007028423,0.000338878,0.001639582,0.001321177,0.001466054,0.9067282,0.000002543474,0.00004105399,0.0001213113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998419,0.0002441077,0.0002108437,0.0000179895,0.0001054065,0.0006661366,0.0002733018,0.00001556359,0.00004769224],"genre_scores_gemma":[0.9997872,0.00001673167,0.00006259801,0.00000633034,0.00001764213,0.000007435927,0.00007388458,0.000008868162,0.00001927103],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05979464,"threshold_uncertainty_score":0.3668504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006313538827166016,"score_gpt":0.2131211123704135,"score_spread":0.2068075735432474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}