{"id":"W2132699732","doi":"10.1002/bit.10262","title":"Controlled shear affinity filtration (CSAF): A new technology for integration of cell separation and protein isolation from mammalian cell cultures","year":2002,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Microfluidic and Bio-sensing Technologies","field":"Engineering","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chinese hamster ovary cell; Chromatography; Membrane; Microfiltration; Elution; Filtration (mathematics); Bioreactor; Chemistry; Adsorption; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000681028,0.0002054864,0.0002975671,0.0003106254,0.00006848836,0.00002335937,0.00009056707,0.0007944416,0.000007494013],"category_scores_gemma":[0.00004912636,0.0001840006,0.00003878372,0.000234792,0.0001032938,0.0001051089,0.00003019011,0.0002153014,0.000001940914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002341664,"about_ca_system_score_gemma":0.000005381918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001712321,"about_ca_topic_score_gemma":0.00001155805,"domain_scores_codex":[0.9992267,0.000007245437,0.0002936877,0.0002312348,0.00005048881,0.0001906186],"domain_scores_gemma":[0.9996617,0.00002881475,0.00007498584,0.0001736099,0.00003274248,0.00002815697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003180735,0.00001852015,0.0000312052,0.00006468601,0.00001824982,5.916634e-7,0.00009632212,0.0001129031,0.9903229,0.0007273438,0.0004161175,0.008159344],"study_design_scores_gemma":[0.001251754,0.0001896775,0.00005245603,0.00004347337,0.00003833752,0.000004620093,0.0001973112,0.05889345,0.9372422,0.0006046523,0.001294878,0.0001872551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7181023,0.004531907,0.2750793,0.0007249813,0.00008019658,0.0006077447,0.00002255663,0.0008052005,0.00004574057],"genre_scores_gemma":[0.9456578,0.000800277,0.05334869,0.000005788446,0.00003396932,0.00003221485,0.00002368975,0.00001709943,0.00008048927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2275554,"threshold_uncertainty_score":0.7503328,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130866801349015,"score_gpt":0.2055759727576723,"score_spread":0.1942673047441822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}