{"id":"W2132699732","doi":"10.1002/bit.10262","title":"Controlled shear affinity filtration (CSAF): A new technology for integration of cell separation and protein isolation from mammalian cell cultures","year":2002,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Microfluidic and Bio-sensing Technologies","field":"Engineering","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chinese hamster ovary cell; Chromatography; Membrane; Microfiltration; Elution; Filtration (mathematics); Bioreactor; Chemistry; Adsorption; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005049731,0.000656366,0.0005311833,0.0006043775,0.000266815,0.0006239708,0.0006918167,0.0004997696,0.0004528635],"category_scores_gemma":[0.0003203288,0.0002935203,0.0004647069,0.000338523,0.0004729347,0.000571169,0.0004420008,0.0007155556,0.0004159345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005861019,"about_ca_system_score_gemma":0.0005076119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008547287,"about_ca_topic_score_gemma":0.0008542772,"domain_scores_codex":[0.9995995,0.00004837468,0.00003474078,0.00008749813,0.0001921376,0.00003769692],"domain_scores_gemma":[0.9998102,0.00004432637,0.00006020912,0.00002705793,0.00003364771,0.00002471863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000399532,0.00001309115,0.0001798554,0.00008437436,0.000009748533,0.00003457332,0.00001793267,0.00008719328,0.9881529,0.0004874673,0.0001764091,0.01071641],"study_design_scores_gemma":[0.00002234136,0.0002207505,0.00148272,0.000008173983,0.00002766763,0.0006334302,0.000009439554,0.001873364,0.9802184,0.0002471216,0.01523566,0.0000209616],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3184379,0.01367173,0.6605744,0.0006472514,0.0004949127,0.0003509617,0.000764749,0.002154038,0.002904121],"genre_scores_gemma":[0.5706574,0.01311418,0.4071949,0.0004258051,0.0003822113,0.0005430644,0.001824764,0.0001257623,0.005731876],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0008547287,"threshold_uncertainty_score":0.004252553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130866801349015,"score_gpt":0.2055759727576723,"score_spread":0.1942673047441822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}