{"id":"W2132700526","doi":"10.1074/jbc.m211307200","title":"Drug Binding in Human P-glycoprotein Causes Conformational Changes in Both Nucleotide-binding Domains","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canadian Institutes of Health Research","funders":"National Cancer Institute","keywords":"ATP-binding cassette transporter; Chemistry; ATP hydrolysis; Binding site; Nucleotide; Cyclic nucleotide-binding domain; Walker motifs; ATPase; Transmembrane domain; Biochemistry; Stereochemistry; Transporter; Enzyme; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006965697,0.0001472963,0.00040905,0.0001172821,0.0000520542,0.00001435767,0.0001069818,0.0001655637,0.0005137876],"category_scores_gemma":[0.0001075789,0.0001011116,0.0001036435,0.0001968825,0.00007626004,0.00006661718,0.00001042412,0.0004871115,0.000003219756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001549438,"about_ca_system_score_gemma":0.0000768467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003270675,"about_ca_topic_score_gemma":0.00001787704,"domain_scores_codex":[0.9987695,0.00002967581,0.0005553684,0.000129979,0.0002424288,0.0002730387],"domain_scores_gemma":[0.999431,0.00004624807,0.0002693943,0.00008217862,0.00004624947,0.0001249182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001176808,0.0001750449,0.0710173,0.0001116538,0.00001986447,0.0005168695,0.0001582094,0.00000565112,0.9274727,0.0002855316,0.00004332527,0.00007620423],"study_design_scores_gemma":[0.003132589,0.0001434092,0.02649528,0.0008023493,0.00002035344,0.0003223295,0.001764303,0.000004036567,0.9643446,0.0005853471,0.002171237,0.0002141901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963444,0.0001733464,0.00001958409,0.0003001158,0.00006384045,0.0001116086,0.000006259153,0.0000105669,0.002970295],"genre_scores_gemma":[0.9986585,0.0001171776,0.0006087419,0.00008292666,0.0001046976,0.000004440326,0.00001557985,0.000008368625,0.0003996135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04452203,"threshold_uncertainty_score":0.5625613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02424094923387153,"score_gpt":0.2676330109931747,"score_spread":0.2433920617593031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}