{"id":"W2132762811","doi":"10.1210/en.2003-1185","title":"Ligand-Selective Dissociation of Activation and Internalization of the Parathyroid Hormone (PTH) Receptor: Conditional Efficacy of PTH Peptide Fragments","year":2004,"lang":"en","type":"article","venue":"Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Internalization; Parathyroid hormone receptor; Parathyroid hormone; G protein-coupled receptor; Receptor; Endocytosis; Chemistry; Cell biology; Endocrinology; Biology; Internal medicine; Calcium; Biochemistry; Hormone receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005039868,0.00007462326,0.0001325772,0.00003538809,0.00003488447,0.000002280375,0.00007897906,0.00007396049,0.000009114067],"category_scores_gemma":[0.0001141598,0.00006244517,0.00004810205,0.00007703506,0.00008132383,0.000006112844,0.00004890596,0.00005391275,5.185458e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001977147,"about_ca_system_score_gemma":0.00004198785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002899826,"about_ca_topic_score_gemma":0.00000375571,"domain_scores_codex":[0.9993897,0.00005019221,0.0002245749,0.0001388113,0.00009831096,0.00009840907],"domain_scores_gemma":[0.9994652,0.00001930588,0.0002700382,0.00009691699,0.0001338216,0.00001473832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001227663,0.00007444526,0.002650634,0.000007106277,0.000068113,6.297357e-8,0.000214363,0.0004850311,0.9930713,0.003069618,0.00009312402,0.000143451],"study_design_scores_gemma":[0.001001585,0.0003504819,0.02837658,0.000017502,0.00001428313,0.00000312067,0.00008112147,0.00000935147,0.96847,0.001501773,0.0001226275,0.00005158698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865803,0.0002151968,0.01284414,0.00004618037,0.00006098186,0.000135672,0.00002001208,0.000002677449,0.00009485341],"genre_scores_gemma":[0.9992867,0.0001973149,0.0002702925,0.00002238866,0.00004321463,0.000005437535,0.0001237109,0.000007098263,0.00004385295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02572594,"threshold_uncertainty_score":0.254644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007008532488881715,"score_gpt":0.236744766453759,"score_spread":0.2297362339648773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}