{"id":"W2132762811","doi":"10.1210/en.2003-1185","title":"Ligand-Selective Dissociation of Activation and Internalization of the Parathyroid Hormone (PTH) Receptor: Conditional Efficacy of PTH Peptide Fragments","year":2004,"lang":"en","type":"article","venue":"Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Biological Sciences","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Internalization; Parathyroid hormone receptor; Parathyroid hormone; G protein-coupled receptor; Receptor; Endocytosis; Chemistry; Cell biology; Endocrinology; Biology; Internal medicine; Calcium; Biochemistry; Hormone receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003214837,0.0003072412,0.0003173166,0.0001331151,0.0001640757,0.0003504097,0.0004226457,0.000445155,0.00142348],"category_scores_gemma":[0.0001948473,0.000227206,0.0004451197,0.0001544362,0.000321314,0.0002997383,0.0004225353,0.0009712037,0.0004214341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005470059,"about_ca_system_score_gemma":0.0003335175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009671384,"about_ca_topic_score_gemma":0.001174656,"domain_scores_codex":[0.9996206,0.00004476628,0.00003321374,0.00009106873,0.0001033266,0.0001069662],"domain_scores_gemma":[0.9998654,0.00003204153,0.0000300864,0.00001887039,0.00001888895,0.00003474979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001072569,0.00001989953,0.0000346351,0.00002277612,0.000004039828,0.00002064966,0.00000917017,0.00004136815,0.9991834,0.0001363605,0.00003379395,0.000386822],"study_design_scores_gemma":[0.00003386239,0.0001887162,0.001265895,0.000003626388,0.00001360257,0.000170961,0.00001271068,0.0008449532,0.9952258,0.00003505304,0.002197685,0.00000721027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910314,0.0013575,0.004798174,0.0001482735,0.00004677444,0.00008162642,0.0006416155,0.000099192,0.001795451],"genre_scores_gemma":[0.9911486,0.0008779577,0.003617316,0.00008532947,0.0000128989,0.00009146347,0.0007831105,0.00005964222,0.003323687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00142348,"threshold_uncertainty_score":0.004761994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007008532488881715,"score_gpt":0.236744766453759,"score_spread":0.2297362339648773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}