{"id":"W2132776501","doi":"10.4049/jimmunol.0902398","title":"MHC Class I Molecules with Superenhanced CD8 Binding Properties Bypass the Requirement for Cognate TCR Recognition and Nonspecifically Activate CTLs","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Cardiff University; Leverhulme Trust; National Health and Medical Research Council; Wellcome Trust","keywords":"T-cell receptor; CD8; Cell biology; Cytotoxic T cell; MHC class I; Biology; CTL*; Major histocompatibility complex; Effector; Degranulation; T cell; Chemistry; Molecular biology; Immunology; Immune system; Receptor; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001220094,0.0003064855,0.0002065388,0.00008223961,0.00007910356,0.0002703152,0.0001891203,0.000254625,0.001376915],"category_scores_gemma":[0.0001436305,0.0001040791,0.0001726682,0.00006483844,0.0001827923,0.0002188703,0.0002180759,0.0007885412,0.0004206979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002733506,"about_ca_system_score_gemma":0.000105195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001025036,"about_ca_topic_score_gemma":0.0002212933,"domain_scores_codex":[0.9998317,0.00003131675,0.000009350732,0.00003062098,0.00004481,0.00005227431],"domain_scores_gemma":[0.9998879,0.0000338945,0.00002250165,0.00002042507,0.00001012294,0.00002511553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002523352,0.00001759139,0.00005821589,0.00001103247,0.000001691213,0.00001877293,0.000003484602,0.00003699559,0.9990774,0.00008024221,0.00001601076,0.0006533473],"study_design_scores_gemma":[0.00001605574,0.0001684576,0.0009934137,0.000002956365,0.000009154432,0.0002149411,0.000008607505,0.0008563685,0.9961472,0.00004249144,0.00153831,0.000002097051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936517,0.0007482782,0.003756009,0.00008239225,0.00001943664,0.00002880719,0.00005038588,0.00004447446,0.001618552],"genre_scores_gemma":[0.993933,0.000338676,0.003832815,0.0001029463,0.00002262886,0.00003331561,0.0001740329,0.00001586437,0.001546701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001376915,"threshold_uncertainty_score":0.004606307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03224765995930534,"score_gpt":0.2390808821366883,"score_spread":0.206833222177383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}