{"id":"W2132779385","doi":"10.1128/mcb.00214-12","title":"Protein Tyrosine Phosphatase <i>α</i> Phosphotyrosyl-789 Binds BCAR3 To Position Cas for Activation at Integrin-Mediated Focal Adhesions","year":2012,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Focal adhesion; Integrin; Biology; Proto-oncogene tyrosine-protein kinase Src; Protein tyrosine phosphatase; Cell biology; Phosphorylation; Tyrosine phosphorylation; Scaffold protein; Phosphatase; Actin cytoskeleton; PTK2; Extracellular matrix; Signal transduction; Cell adhesion; Cytoskeleton; Receptor; Biochemistry; Cell; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003148436,0.0003883881,0.0003105856,0.00009669134,0.0002315947,0.00002915441,0.0002168899,0.0004159378,0.0000359864],"category_scores_gemma":[0.0003148567,0.0003703767,0.0001532063,0.0001965663,0.0001422595,0.0000174424,0.0003403258,0.0001388295,0.00003750749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007495405,"about_ca_system_score_gemma":0.00006107817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001130759,"about_ca_topic_score_gemma":0.00001889235,"domain_scores_codex":[0.9980125,0.0001272175,0.0003509649,0.0006608735,0.0001272373,0.000721225],"domain_scores_gemma":[0.9988086,0.00003253928,0.0001377605,0.0005011145,0.0001343628,0.0003856644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006078506,0.0001504064,0.0007478216,0.00003451774,0.00006537605,0.000005010967,0.00003454196,0.00000579576,0.9905744,0.004540773,0.001510765,0.001722804],"study_design_scores_gemma":[0.001099114,0.001012143,0.0002703444,0.00003024853,0.00005067076,0.00002343097,0.00002082065,0.00002570698,0.9460232,0.0001526993,0.05085553,0.0004361079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9147492,0.01630071,0.06564951,0.0006399943,0.0002118022,0.001626623,0.0007144389,0.00004721003,0.00006051589],"genre_scores_gemma":[0.9860272,0.00005710334,0.003092686,0.001460357,0.0002106242,0.0006256062,0.008271042,0.00006780867,0.000187552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07127803,"threshold_uncertainty_score":0.9998748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008689614500418625,"score_gpt":0.2459688490784313,"score_spread":0.2372792345780126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}