{"id":"W2132798572","doi":"10.1038/sj.bjc.6605279","title":"The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers","year":2009,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto; Cancer Care Ontario; Centre Hospitalier Universitaire Sainte-Justine; Université Laval; Université de Montréal; Centre hospitalier universitaire de Québec","funders":"Medical Research Council; Canadian Institutes of Health Research; National Institute for Health and Care Research; Ministerio de Ciencia e Innovación; National Breast Cancer Foundation; National Cancer Institute; KWF Kankerbestrijding; National Institutes of Health; National Health and Medical Research Council; Cancer Research UK; Deutsche Krebshilfe; Cancer Care Ontario; Royal Marsden NHS Foundation Trust; Deutsches Krebsforschungszentrum; Helsingin ja Uudenmaan Sairaanhoitopiiri","keywords":"Breast cancer; Single-nucleotide polymorphism; Genotype; SNP; Oncology; Hazard ratio; Internal medicine; Carcinogenesis; Medicine; Allele; Cancer; Confidence interval; Genetics; Biology; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001349335,0.0006509328,0.001090874,0.001509868,0.0004299913,0.0005907963,0.0004921406,0.0009055824,0.003132521],"category_scores_gemma":[0.002916517,0.0003842163,0.001364126,0.001528929,0.0003459849,0.0003033144,0.0004229546,0.0004344897,0.0003357135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001639183,"about_ca_system_score_gemma":0.0002707235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002374483,"about_ca_topic_score_gemma":0.001902644,"domain_scores_codex":[0.9991016,0.0002651364,0.00009406155,0.0002946961,0.0001409178,0.0001035992],"domain_scores_gemma":[0.9981835,0.0006852695,0.0005277296,0.0002626397,0.0000852767,0.0002555064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007211539,0.00006898961,0.972214,0.00008391245,0.002527085,0.001257361,0.0002003631,0.0003084496,0.009620017,0.00007455957,0.000217256,0.006216365],"study_design_scores_gemma":[0.0001242532,0.0004502797,0.9931639,0.00002078122,0.002113584,0.002070501,0.0001041739,0.0005514543,0.0005365961,0.0002428544,0.0006073732,0.00001423563],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997822,0.0009811737,0.0004053688,0.00003609851,0.00001979794,0.00001063453,0.0003832827,0.00001499281,0.0003265787],"genre_scores_gemma":[0.9991385,0.0001311645,0.0001476053,0.00001464903,0.00001856854,0.000009911544,0.0003383945,0.000009235069,0.0001920585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003132521,"threshold_uncertainty_score":0.01047933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005273202937819501,"score_gpt":0.23216079520773,"score_spread":0.2268875922699105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}