{"id":"W2132800651","doi":"10.1093/hmg/dds344","title":"Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis","year":2012,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"King's College London; Medical Research Council; National Institute for Health and Care Research; Wellcome Trust","keywords":"Biology; Linkage disequilibrium; Psoriasis; Genetics; Major histocompatibility complex; Single-nucleotide polymorphism; Allele; Human leukocyte antigen; Haplotype; Locus (genetics); Genetic association; Genome-wide association study; Immunology; Immune system; Gene; Genotype; Antigen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007183473,0.0004973206,0.0003657498,0.0005981213,0.0003559987,0.0005654893,0.0005746108,0.0004005836,0.003432503],"category_scores_gemma":[0.002536562,0.0002478382,0.0009180327,0.0005557309,0.0006565878,0.0001592515,0.0006181864,0.001008247,0.0002490876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002074598,"about_ca_system_score_gemma":0.0003161287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002610294,"about_ca_topic_score_gemma":0.003215922,"domain_scores_codex":[0.9993017,0.000113325,0.00003565539,0.0003218968,0.0001295447,0.00009795079],"domain_scores_gemma":[0.9976235,0.001207642,0.0004769614,0.0002084574,0.0001279594,0.0003554333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005127385,0.0004151801,0.458937,0.0002283074,0.001105205,0.005066045,0.0005978338,0.001780907,0.4897791,0.003237168,0.002078132,0.03164774],"study_design_scores_gemma":[0.0002519281,0.0003840676,0.9671243,0.00002662215,0.0006915077,0.00456409,0.000117392,0.008650353,0.01502109,0.001745145,0.001360533,0.0000629022],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922298,0.0002071456,0.005918329,0.0001351348,0.00001610393,0.00002144047,0.0006637331,0.000156717,0.0006516774],"genre_scores_gemma":[0.9966308,0.00005609096,0.002452153,0.00008325644,0.00001362288,0.00001415155,0.0004205053,0.00004620367,0.0002831311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003432503,"threshold_uncertainty_score":0.01148289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03994678534483245,"score_gpt":0.2693160518826858,"score_spread":0.2293692665378534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}