{"id":"W2132809955","doi":"10.1074/mcp.m111.013672","title":"Quantitative Proteomic Analysis of Type III Secretome of Enteropathogenic Escherichia coli Reveals an Expanded Effector Repertoire for Attaching/Effacing Bacterial Pathogens","year":2012,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"British Columbia Knowledge Development Fund; Canadian Institutes of Health Research; Genome British Columbia; Genome Canada; Howard Hughes Medical Institute","keywords":"Effector; Virulence; Biology; Microbiology; Secretion; Enteropathogenic Escherichia coli; Bacterial adhesin; Pathogen; Escherichia coli; Salmonella enterica; Type three secretion system; Citrobacter rodentium; Stable isotope labeling by amino acids in cell culture; Proteome; Intimin; Virulence factor; Enterobacteriaceae; Proteomics; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00163646,0.0004216247,0.0009157715,0.0002430953,0.000146924,0.0000275308,0.0004008233,0.000303234,0.00001554524],"category_scores_gemma":[0.0008738943,0.0004149186,0.0005866313,0.0006296964,0.0001983645,0.00003145569,0.0003113839,0.0001938859,0.000001732166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007842598,"about_ca_system_score_gemma":0.0001631147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000532119,"about_ca_topic_score_gemma":0.00001143454,"domain_scores_codex":[0.9968243,0.0007100209,0.0007562786,0.0005857471,0.0003618487,0.0007618465],"domain_scores_gemma":[0.9977742,0.00005473584,0.0005837846,0.0008635701,0.0004675765,0.0002561547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001474065,0.0003370712,0.01104321,0.0002648999,0.001884099,0.000002931278,0.0006713113,0.0001859921,0.9839619,0.00009213181,0.0000123559,0.00007000832],"study_design_scores_gemma":[0.001102292,0.001880735,0.00255326,0.00004519806,0.0007673976,0.000002183105,0.0001720706,0.001733013,0.9912601,0.00001253956,0.00006829668,0.0004029268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649171,0.001220982,0.0307317,0.000008856468,0.0001917543,0.00260595,0.0002784115,0.00001953083,0.00002569203],"genre_scores_gemma":[0.9664785,0.00007198839,0.03185391,0.0000306915,0.0001468974,0.0004462411,0.0008295211,0.00008936293,0.00005283588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008489949,"threshold_uncertainty_score":0.9998302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02099407333039062,"score_gpt":0.3039747187746149,"score_spread":0.2829806454442243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}