{"id":"W2132865753","doi":"10.1128/aac.49.4.1626-1628.2005","title":"Role of P-Glycoprotein in Distribution of Nelfinavir across the Blood-Mammary Tissue Barrier and Blood-Brain Barrier","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences","keywords":"Nelfinavir; Blood–brain barrier; Mammary gland; P-glycoprotein; Glycoprotein; Protease; Biology; Pharmacology; Blot; Distribution (mathematics); Internal medicine; Chemistry; Endocrinology; Virology; Molecular biology; Medicine; Biochemistry; Multiple drug resistance; Virus; Central nervous system; Enzyme; Breast cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533507,0.0002377105,0.0002523847,0.0003000294,0.0001852994,0.0005980344,0.0002125748,0.0005009553,0.0005557413],"category_scores_gemma":[0.0003680333,0.0001720159,0.0001326189,0.0001092999,0.0004042344,0.0008917447,0.0001457561,0.0004368792,0.000261597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000424065,"about_ca_system_score_gemma":0.0002327064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005267474,"about_ca_topic_score_gemma":0.0004205087,"domain_scores_codex":[0.9998349,0.00006240912,0.000007012381,0.00002732208,0.00003226895,0.0000359549],"domain_scores_gemma":[0.9998482,0.0000468791,0.00003374048,0.00001108434,0.00002887008,0.00003122812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006921176,0.00003828775,0.0009197816,0.00005096669,0.00001113623,0.0002273075,0.00005675696,0.00004125807,0.9918917,0.0005330762,0.00005235732,0.005485252],"study_design_scores_gemma":[0.00006285762,0.001385795,0.05235443,0.00002754342,0.00006046394,0.002777923,0.0003648451,0.002606165,0.9352622,0.001140149,0.003936453,0.00002113574],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866036,0.008421132,0.003126266,0.0002708174,0.00001235952,0.00001553413,0.00008708065,0.00005222092,0.001411044],"genre_scores_gemma":[0.9949377,0.002137388,0.001960839,0.00004496826,0.00001108517,0.00001818647,0.00007196585,0.00001089583,0.0008071135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005980344,"threshold_uncertainty_score":0.003076851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005746785305217291,"score_gpt":0.2526463868342588,"score_spread":0.2468996015290415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}