{"id":"W2132875315","doi":"10.1128/iai.01109-06","title":"Heptose I Glycan Substitutions on<i>Neisseria gonorrhoeae</i>Lipooligosaccharide Influence C4b-Binding Protein Binding and Serum Resistance","year":2007,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Biology; Complement system; Binding site; Glycan; Neisseria gonorrhoeae; Factor H; Plasma protein binding; Microbiology; Mutant; Alternative complement pathway; Biochemistry; Glycoprotein; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006157889,0.0002134121,0.0002176179,0.0002663423,0.001141236,0.00006911369,0.0001105552,0.0001390148,0.0001889427],"category_scores_gemma":[0.0002338372,0.0002150793,0.00004894192,0.000302993,0.0002545284,0.0002786281,0.0001146241,0.0003667142,0.0001339713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001089627,"about_ca_system_score_gemma":0.00004706366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007688808,"about_ca_topic_score_gemma":0.001311121,"domain_scores_codex":[0.9987276,0.0002130069,0.000362507,0.0002872059,0.00002700727,0.0003827337],"domain_scores_gemma":[0.9992168,0.0001604231,0.0001679077,0.0003174807,0.00007552368,0.00006187921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002988635,0.0001611763,0.1848169,0.0001096903,0.0001025481,0.000002272531,0.0003465901,0.000004286671,0.8076977,0.004618169,0.0002204196,0.001621399],"study_design_scores_gemma":[0.001606696,0.0002285856,0.7960297,0.0004827686,0.00005604021,0.00009007649,0.0006008312,0.000001716924,0.1678463,0.0002366902,0.03235133,0.0004692492],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969449,0.0004798426,0.00007527362,0.00008403572,0.0004011323,0.0005051999,0.00006962297,0.0001582401,0.001281735],"genre_scores_gemma":[0.9983785,0.00007586948,0.00002263461,0.00005824246,0.00002226478,0.00004193446,0.00005012334,0.00001290252,0.001337497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6398513,"threshold_uncertainty_score":0.8777582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455039925037444,"score_gpt":0.263726528542929,"score_spread":0.2491761292925546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}