{"id":"W2132875315","doi":"10.1128/iai.01109-06","title":"Heptose I Glycan Substitutions on<i>Neisseria gonorrhoeae</i>Lipooligosaccharide Influence C4b-Binding Protein Binding and Serum Resistance","year":2007,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Biology; Complement system; Binding site; Glycan; Neisseria gonorrhoeae; Factor H; Plasma protein binding; Microbiology; Mutant; Alternative complement pathway; Biochemistry; Glycoprotein; Genetics; Gene; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005853971,0.0001910336,0.0001081759,0.00008203306,0.00007338545,0.0001919965,0.0001375781,0.0001680852,0.001376584],"category_scores_gemma":[0.0001559986,0.000123766,0.0001250179,0.0000934609,0.000161338,0.0001109094,0.0001483965,0.000272316,0.0001937482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00024496,"about_ca_system_score_gemma":0.0001234638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002590064,"about_ca_topic_score_gemma":0.003028419,"domain_scores_codex":[0.9998953,0.00001713751,0.00001174446,0.00001538281,0.00002448596,0.00003586362],"domain_scores_gemma":[0.9998943,0.00002631983,0.00002675435,0.00001063727,0.00001077041,0.00003131698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002322735,0.00005671758,0.0006044325,0.00001237202,0.000004439356,0.00003854705,0.00002092898,0.00006606246,0.9981426,0.00005173491,0.0000305687,0.0007393273],"study_design_scores_gemma":[0.00002192852,0.0009387069,0.02398334,0.000005841008,0.0000196655,0.0001796311,0.00008350385,0.0008394957,0.9728084,0.00003348707,0.001075966,0.00001006617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991875,0.00005176404,0.00007372936,0.00001084421,0.000002990693,0.000005291066,0.00008619828,0.000008039295,0.0005735386],"genre_scores_gemma":[0.9990062,0.00007070171,0.0002451921,0.00002273608,0.000001453394,0.000005938668,0.0001398756,0.000007419548,0.0005005173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002590064,"threshold_uncertainty_score":0.005149961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01455039925037444,"score_gpt":0.263726528542929,"score_spread":0.2491761292925546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}