{"id":"W2132886417","doi":"10.1016/j.cell.2015.07.026","title":"Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer","year":2015,"lang":"en","type":"article","venue":"Cell","topic":"Liver physiology and pathology","field":"Medicine","cited_by":490,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Hepatocyte; Biology; Carcinogenesis; Cancer research; Hepatocellular carcinoma; Liver regeneration; SOX9; Liver cancer; Regeneration (biology); Hepatocyte growth factor; Population; Cell biology; Cancer; Gene; Transcription factor; Genetics; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001612137,0.0002523861,0.0002215479,0.0002837135,0.0001868208,0.000756576,0.0001707028,0.0003978399,0.004286714],"category_scores_gemma":[0.00009708309,0.0001727339,0.0002137656,0.0001527193,0.0001786486,0.0003502975,0.0003054269,0.0006603625,0.001788975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000170887,"about_ca_system_score_gemma":0.0001040459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000155676,"about_ca_topic_score_gemma":0.0003144326,"domain_scores_codex":[0.9998453,0.00002085457,0.00001075714,0.00003350991,0.0000530719,0.00003658801],"domain_scores_gemma":[0.999837,0.00002833608,0.00002194457,0.00004250226,0.00002112314,0.00004906764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003745497,0.00006396101,0.0006781172,0.0000353875,0.0000125878,0.0001657006,0.00004847172,0.00008648273,0.9943581,0.0006221963,0.0001532195,0.003401177],"study_design_scores_gemma":[0.00003289148,0.0004800129,0.003499152,0.000005579585,0.00002690514,0.0007597591,0.00009247581,0.000859795,0.9852313,0.0002060256,0.008797769,0.000008278169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755029,0.0009171243,0.01209919,0.0001791239,0.0001376381,0.00005569422,0.0004794173,0.0003304809,0.01029835],"genre_scores_gemma":[0.9850289,0.0002333793,0.003148859,0.00007773841,0.00002387136,0.00003376871,0.0005860723,0.00006080683,0.01080664],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004286714,"threshold_uncertainty_score":0.01434046,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03772076267952117,"score_gpt":0.2860674206308626,"score_spread":0.2483466579513414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}