{"id":"W2132913823","doi":"10.1128/iai.00735-07","title":"Comparisons of Mutants Lacking the Golgi UDP-Galactose or GDP-Mannose Transporters Establish that Phosphoglycans Are Important for Promastigote but Not Amastigote Virulence in <i>Leishmania major</i>","year":2007,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; McMaster University","keywords":"Lipophosphoglycan; Biology; Amastigote; Virulence; Glycoconjugate; Mutant; Leishmania; Mannose; Microbiology; Leishmania major; Leishmania mexicana; Macrophage; Leishmania donovani; Phenotype; Cell biology; Biochemistry; Gene; Parasite hosting; Immunology; In vitro; Leishmaniasis; Visceral leishmaniasis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001772119,0.0002989824,0.0006470809,0.0002705812,0.0004082252,0.00005935107,0.0001758643,0.0001388332,0.00003674002],"category_scores_gemma":[0.0004949143,0.0002103444,0.0001464242,0.0006030638,0.0004810234,0.0003316404,0.00008457698,0.0007172268,0.000001999725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000145761,"about_ca_system_score_gemma":0.0001461959,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.007058905,"about_ca_topic_score_gemma":0.0198685,"domain_scores_codex":[0.9977843,0.00009249162,0.0007410126,0.0003460042,0.0004546636,0.0005815655],"domain_scores_gemma":[0.9982154,0.0004624577,0.0003998985,0.0004549633,0.0002955433,0.000171671],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00354366,0.0006296957,0.9589462,0.0005347743,0.0001897139,0.00007591966,0.002330701,0.00001008112,0.02854257,0.00005945001,0.0005831923,0.00455408],"study_design_scores_gemma":[0.002953694,0.0005906854,0.9328544,0.0005182447,0.0001110202,0.00007817951,0.002625171,0.0002917822,0.05618054,0.00002454993,0.003556598,0.0002151754],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952475,0.0002866819,0.001569028,0.0006560576,0.00022646,0.001463593,0.0001014876,0.00007116556,0.0003780419],"genre_scores_gemma":[0.9981007,0.001006816,0.0002644669,0.0002651849,0.00005083491,0.00006941649,0.00002232008,0.00003464406,0.0001856176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02763797,"threshold_uncertainty_score":0.9995532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05440739424256743,"score_gpt":0.3222764564795794,"score_spread":0.267869062237012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}