{"id":"W2132963469","doi":"10.1093/toxsci/kfm123","title":"Transgenic Rescue of Methotrexate-Induced Teratogenicity in Drosophila melanogaster","year":2007,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Dihydrofolate reductase; Drosophila melanogaster; Methotrexate; Biology; Antifolate; Transgene; Gene; Pharmacology; Genetics; Antimetabolite; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009774038,0.00009025165,0.0001327575,0.00005342203,0.00003804645,0.000008316871,0.0002300761,0.0001287233,0.00004242912],"category_scores_gemma":[0.00008425119,0.00006701034,0.00006299522,0.0002425205,0.0001407422,0.00000284916,0.00005200374,0.00007124516,0.000001937104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007171279,"about_ca_system_score_gemma":0.00002413559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001527455,"about_ca_topic_score_gemma":0.0002355372,"domain_scores_codex":[0.9990555,0.00004322513,0.0002264635,0.000266965,0.0001352006,0.0002726204],"domain_scores_gemma":[0.9997498,0.00003248226,0.00002716423,0.0001105442,0.00001696604,0.00006297693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002939582,0.00004924313,0.004989109,0.000003796349,0.000003863542,0.000002910248,0.00004829648,0.0003746222,0.9925571,0.0001223597,0.000006247071,0.001813035],"study_design_scores_gemma":[0.0002145926,0.0005402047,0.07794355,0.000005077857,0.000003161808,0.0000048641,0.00007618772,0.00007109879,0.9206758,0.0001275904,0.0002433787,0.00009449282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949912,0.00019693,0.00243485,0.00008030488,0.00007226424,0.000100157,0.000001865454,0.000006503878,0.002115917],"genre_scores_gemma":[0.9978761,0.00002327028,0.00191044,0.00009707925,0.00004983765,0.000003447681,0.000001535458,0.000003163018,0.00003509646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07295444,"threshold_uncertainty_score":0.2732602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03661486726676683,"score_gpt":0.364009946491591,"score_spread":0.3273950792248242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}