{"id":"W2132963469","doi":"10.1093/toxsci/kfm123","title":"Transgenic Rescue of Methotrexate-Induced Teratogenicity in Drosophila melanogaster","year":2007,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Dihydrofolate reductase; Drosophila melanogaster; Methotrexate; Biology; Antifolate; Transgene; Gene; Pharmacology; Genetics; Antimetabolite; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000156336,0.0004060003,0.0002221173,0.00042972,0.0003255128,0.0003315001,0.0004409352,0.000454256,0.0022579],"category_scores_gemma":[0.0001415511,0.0002838479,0.0003126,0.0001940553,0.0002877026,0.0001427364,0.0002905803,0.0009140291,0.0007627859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005973552,"about_ca_system_score_gemma":0.000316538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002817807,"about_ca_topic_score_gemma":0.005495262,"domain_scores_codex":[0.9998203,0.0000278521,0.00003138214,0.00004437834,0.0000565164,0.00001970252],"domain_scores_gemma":[0.9997917,0.00004769017,0.0000708623,0.00002701434,0.00002483919,0.00003795381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002710038,0.00001010146,0.0001096555,0.00003389147,0.000005710634,0.000102457,0.00002443965,0.0000983491,0.998558,0.0001967473,0.00006709238,0.0007664734],"study_design_scores_gemma":[0.00003453734,0.0001074854,0.004599558,0.00002615694,0.00002748575,0.0005077065,0.00008305923,0.001923988,0.9838052,0.0001010863,0.008769947,0.00001388239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9657093,0.001466653,0.01689733,0.000364757,0.0001131696,0.0002578058,0.007393007,0.0005386804,0.00725928],"genre_scores_gemma":[0.9520268,0.002204929,0.01626597,0.0002334877,0.00001916432,0.0002954642,0.004670769,0.000330187,0.02395329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002817807,"threshold_uncertainty_score":0.007553458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03661486726676683,"score_gpt":0.364009946491591,"score_spread":0.3273950792248242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}