{"id":"W2133003441","doi":"10.1128/aem.02081-08","title":"Reconfiguring the Quorum-Sensing Regulator SdiA of<i>Escherichia coli</i>To Control Biofilm Formation via Indole and<i>N</i>-Acylhomoserine Lactones","year":2009,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Army Research Office; Institute of Genetics; National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health; Keio University","keywords":"Biofilm; Quorum sensing; Tryptophanase; Indole test; Microbiology; Biology; Homoserine; Escherichia coli; Gene; Bacteria; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001363515,0.0003997289,0.0002995532,0.0001263429,0.0001042019,0.0004058091,0.0003078382,0.000274051,0.0004519157],"category_scores_gemma":[0.0001695934,0.0001587156,0.0003608922,0.0001451623,0.0002484141,0.0001628966,0.0003310867,0.0005278848,0.0003080454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003353655,"about_ca_system_score_gemma":0.0002272751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006882708,"about_ca_topic_score_gemma":0.0007345781,"domain_scores_codex":[0.9998513,0.00001636804,0.00002111937,0.00003704869,0.00004245402,0.00003169607],"domain_scores_gemma":[0.9998649,0.00001697995,0.00005305362,0.00001671901,0.00001728347,0.00003102587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004311761,0.00001647683,0.0001909897,0.0000155538,0.000003972246,0.00001970353,0.000007886657,0.00009841334,0.99897,0.00002917731,0.00001713826,0.0005876372],"study_design_scores_gemma":[0.00001113021,0.0001496521,0.002483209,0.000004959474,0.00001614313,0.0001080307,0.00002875684,0.001809534,0.9936665,0.00002194387,0.0016901,0.00001008559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995335,0.0002215545,0.003363673,0.00008733415,0.00002494707,0.00002889119,0.0002860983,0.0001239644,0.0005284298],"genre_scores_gemma":[0.9898909,0.0001828563,0.007891435,0.0001025098,0.000006265909,0.00004101228,0.0007563314,0.00005827325,0.001070344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006882708,"threshold_uncertainty_score":0.00243324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003251689113612833,"score_gpt":0.1700474611709054,"score_spread":0.1667957720572925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}