{"id":"W2133003441","doi":"10.1128/aem.02081-08","title":"Reconfiguring the Quorum-Sensing Regulator SdiA of<i>Escherichia coli</i>To Control Biofilm Formation via Indole and<i>N</i>-Acylhomoserine Lactones","year":2009,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Army Research Office; Institute of Genetics; National Institute of Biomedical Imaging and Bioengineering; National Institutes of Health; Keio University","keywords":"Biofilm; Quorum sensing; Tryptophanase; Indole test; Microbiology; Biology; Homoserine; Escherichia coli; Gene; Bacteria; Chemistry; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117813,0.0001740279,0.0002104135,0.00002401862,0.0001214451,0.00001520191,0.00006574461,0.0001506812,0.000006384274],"category_scores_gemma":[0.000003612404,0.0001380647,0.00003636618,0.00003290741,0.0001636913,0.000005908057,0.00006730114,0.00007133788,0.000004067074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009676653,"about_ca_system_score_gemma":0.000005507572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001377596,"about_ca_topic_score_gemma":0.00000701985,"domain_scores_codex":[0.9992056,0.00003603931,0.0002332922,0.0002669524,0.00002435862,0.0002337643],"domain_scores_gemma":[0.9996512,0.00001218858,0.0001034962,0.000167508,0.000004460828,0.00006115699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001693069,0.00001916608,0.0001051535,0.000006373225,0.00002116536,4.589891e-7,0.00007300306,0.00000527508,0.9874133,0.00003546159,0.00006898867,0.01208233],"study_design_scores_gemma":[0.0007091227,0.0002569662,0.007232826,0.000008453608,0.00002074519,0.00007604114,0.0001217826,0.00002763295,0.980333,0.00002242929,0.01100842,0.0001825392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983971,0.0002897831,0.0003133348,0.0004768789,0.0000689615,0.0002810083,0.00004432684,0.000007781665,0.0001207885],"genre_scores_gemma":[0.9970282,0.0001786227,0.0007304763,0.001796804,0.00009162272,0.000002663946,0.0001398652,0.00001232649,0.00001946063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01189979,"threshold_uncertainty_score":0.5630116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003251689113612833,"score_gpt":0.1700474611709054,"score_spread":0.1667957720572925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}