{"id":"W2133005125","doi":"10.1002/psc.2441","title":"Improved anticancer potency by head‐to‐tail cyclization of short cationic anticancer peptides containing a lipophilic <i>β</i><sup>2,2</sup>‐amino acid","year":2012,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Medical Research Council; Norges Forskningsråd; Alberta Cancer Foundation","keywords":"Chemistry; Cyclic peptide; Peptide; Cytotoxicity; Amino acid; Native chemical ligation; Tetrapeptide; Potency; Biochemistry; Stereochemistry; In vitro; Chemical synthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00101785,0.0001566531,0.0003117621,0.0001272115,0.0001293698,0.00004709188,0.0004542921,0.00007642374,0.00004433815],"category_scores_gemma":[0.0006368085,0.0001286527,0.0001791015,0.000550455,0.0003133119,0.00006817518,0.0001093599,0.0001190468,0.000003388219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007932579,"about_ca_system_score_gemma":0.0002513574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005020754,"about_ca_topic_score_gemma":0.00001208533,"domain_scores_codex":[0.9981969,0.00003783143,0.0005788725,0.0002642102,0.0005042506,0.0004179634],"domain_scores_gemma":[0.998579,0.00002705004,0.0003238329,0.0002759901,0.0004945066,0.000299667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004141583,0.0000950926,0.0184123,0.00001164175,0.00004026265,2.985229e-7,0.0001538373,0.0001538968,0.9752145,0.00001310312,0.0005179979,0.005345647],"study_design_scores_gemma":[0.0002252901,0.0002839345,0.006181935,0.00007625345,0.00009024945,0.00001939317,0.0002717499,0.0007120659,0.9893612,0.00002227393,0.002560849,0.0001948235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947498,0.001089921,0.003188596,0.0004752109,0.00007783256,0.00008375511,0.00001120242,0.000003515159,0.0003201688],"genre_scores_gemma":[0.9969713,0.0003777368,0.001709956,0.0003378766,0.0004325393,0.000004136879,0.000005518634,0.00001351914,0.0001474278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01414668,"threshold_uncertainty_score":0.5246306,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057707309241944,"score_gpt":0.2758782276093893,"score_spread":0.2653011545169698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}