{"id":"W2133005125","doi":"10.1002/psc.2441","title":"Improved anticancer potency by head‐to‐tail cyclization of short cationic anticancer peptides containing a lipophilic <i>β</i><sup>2,2</sup>‐amino acid","year":2012,"lang":"en","type":"article","venue":"Journal of Peptide Science","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Medical Research Council; Norges Forskningsråd; Alberta Cancer Foundation","keywords":"Chemistry; Cyclic peptide; Peptide; Cytotoxicity; Amino acid; Native chemical ligation; Tetrapeptide; Potency; Biochemistry; Stereochemistry; In vitro; Chemical synthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00011884,0.0003105146,0.0001885192,0.00009743227,0.00006417379,0.0001751873,0.0001350085,0.0001893273,0.0005203962],"category_scores_gemma":[0.0001761622,0.00008873933,0.0001634737,0.0001014753,0.0001380217,0.0002003857,0.0001459427,0.0003121786,0.0001623062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00013073,"about_ca_system_score_gemma":0.0001149459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001432029,"about_ca_topic_score_gemma":0.000167393,"domain_scores_codex":[0.9999233,0.00001598954,0.000008121858,0.00001513868,0.00001538265,0.00002204752],"domain_scores_gemma":[0.9998862,0.00001754138,0.00004158493,0.00000780112,0.00001471956,0.00003218353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001514235,0.00001386782,0.00007565262,0.00002729899,0.000003991351,0.00004825274,0.00001043117,0.000225037,0.997583,0.00004160166,0.00001358966,0.001805789],"study_design_scores_gemma":[0.00002547182,0.001019127,0.0008401463,0.000003643053,0.00001301667,0.0001839052,0.00000998538,0.0006768597,0.9959689,0.0000184472,0.001233804,0.000006631391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975861,0.0005793791,0.001054075,0.00002560952,0.00001141662,0.00001954513,0.00004866907,0.00002154402,0.000653607],"genre_scores_gemma":[0.9965789,0.0003842391,0.002295632,0.00003982984,0.00001032871,0.00001629597,0.0001064774,0.00001452842,0.000553767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005203962,"threshold_uncertainty_score":0.001740932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01057707309241944,"score_gpt":0.2758782276093893,"score_spread":0.2653011545169698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}