{"id":"W2133013045","doi":"10.1124/dmd.31.6.748","title":"IN VITRO METABOLISM OF CHLOROQUINE: IDENTIFICATION OF CYP2C8, CYP3A4, AND CYP2D6 AS THE MAIN ISOFORMS CATALYZING N-DESETHYLCHLOROQUINE FORMATION","year":2003,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":185,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"CYP3A4; CYP2C8; Metabolite; Microsome; Cytochrome P450; Ketoconazole; CYP3A; Pharmacology; CYP2D6; Hydroxylation; Chemistry; Metabolism; In vivo; Biology; In vitro; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002270536,0.0003010611,0.0005427399,0.0003311588,0.0002304439,0.0000360993,0.0002103094,0.0001940093,0.00006894411],"category_scores_gemma":[0.0001472131,0.0002376763,0.0001111001,0.0004922968,0.0003466335,0.0006683139,0.00008682647,0.0004015234,0.000009326162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002081123,"about_ca_system_score_gemma":0.0000564246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001138625,"about_ca_topic_score_gemma":0.00001496694,"domain_scores_codex":[0.9974073,0.0005787013,0.0009730964,0.0003535982,0.0002901849,0.0003971117],"domain_scores_gemma":[0.9986261,0.0002423171,0.000536354,0.0002796829,0.0001496187,0.0001659437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004704624,0.0002297215,0.0001584954,0.0001497468,0.00007685077,0.000004200902,0.004419874,0.000121223,0.9511492,0.03197056,0.0001151826,0.01113451],"study_design_scores_gemma":[0.00261947,0.00001624674,0.009544611,0.00001720981,0.000459353,0.00005807906,0.001035437,0.001312012,0.9625477,0.01045923,0.01166611,0.0002646034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788749,0.01738335,0.0004764115,0.0006540774,0.0007668547,0.0006661811,0.0002788211,0.00001870151,0.0008806653],"genre_scores_gemma":[0.9927436,0.005977403,0.0001940011,0.000583873,0.0001270617,0.0000840047,0.0001213994,0.00002595908,0.0001427393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02151133,"threshold_uncertainty_score":0.9692156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02377139676104275,"score_gpt":0.345650322664084,"score_spread":0.3218789259030413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}