{"id":"W2133013045","doi":"10.1124/dmd.31.6.748","title":"IN VITRO METABOLISM OF CHLOROQUINE: IDENTIFICATION OF CYP2C8, CYP3A4, AND CYP2D6 AS THE MAIN ISOFORMS CATALYZING N-DESETHYLCHLOROQUINE FORMATION","year":2003,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":185,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"CYP3A4; CYP2C8; Metabolite; Microsome; Cytochrome P450; Ketoconazole; CYP3A; Pharmacology; CYP2D6; Hydroxylation; Chemistry; Metabolism; In vivo; Biology; In vitro; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007806263,0.0005660116,0.0007802269,0.0002865548,0.0003946727,0.000410762,0.0004256995,0.0005304506,0.001466407],"category_scores_gemma":[0.001081849,0.0003195565,0.0005814731,0.0004821669,0.0003189274,0.0002373481,0.0002824792,0.0007191817,0.0004458293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008148646,"about_ca_system_score_gemma":0.0005018638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009072451,"about_ca_topic_score_gemma":0.0114149,"domain_scores_codex":[0.9989525,0.0005261772,0.00009226947,0.0001479366,0.0001605564,0.0001205415],"domain_scores_gemma":[0.9992501,0.0003439998,0.00008869359,0.000121582,0.000135993,0.00005955639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001743182,0.0002282942,0.002542371,0.0001591706,0.0001120244,0.0001241527,0.0001064071,0.001700868,0.9879059,0.0001004068,0.0002832975,0.004994028],"study_design_scores_gemma":[0.00006887924,0.001273909,0.005314133,0.000006647679,0.0001198078,0.0002330546,0.0000240702,0.002561113,0.9891313,0.00003781513,0.001213521,0.00001573689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752933,0.009907746,0.01063994,0.0002146307,0.000112724,0.00008680047,0.001657194,0.0001041797,0.00198348],"genre_scores_gemma":[0.9884214,0.002203441,0.004665039,0.00006592812,0.00004266393,0.00004438937,0.002895367,0.00002908484,0.001632787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009072451,"threshold_uncertainty_score":0.01803929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02377139676104275,"score_gpt":0.345650322664084,"score_spread":0.3218789259030413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}