{"id":"W2133024109","doi":"10.1158/0008-5472.can-10-3040","title":"Cell Cycle Regulator ING4 Is a Suppressor of Melanoma Angiogenesis That Is Regulated by the Metastasis Suppressor BRMS1","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Mechanisms of cancer metastasis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health Research Institute; University of British Columbia; Vancouver Coastal Health","funders":"Canadian Institutes of Health Research","keywords":"Angiogenesis; Matrigel; Gene knockdown; Cancer research; Melanoma; Biology; CD31; HIF1A; Cell migration; Cell growth; Cell cycle; Cell biology; Metastasis; Human umbilical vein endothelial cell; Cell; Apoptosis; Umbilical vein; Cancer; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009072285,0.0005664701,0.0002735915,0.0003916873,0.0002752728,0.0002532981,0.0002043958,0.0002105183,0.001267042],"category_scores_gemma":[0.00008033576,0.0001328762,0.0002455579,0.0001900437,0.0001922856,0.0001426553,0.000198278,0.0004613754,0.0004356939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004353494,"about_ca_system_score_gemma":0.000281128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006808303,"about_ca_topic_score_gemma":0.001173905,"domain_scores_codex":[0.9999264,0.00001088143,0.00000434632,0.00001400248,0.00002250331,0.00002180405],"domain_scores_gemma":[0.9999352,0.000004932166,0.00002581196,0.000004786399,0.000009689895,0.00001960471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001320758,0.00002772354,0.000486616,0.00006159571,0.000006697354,0.0001135752,0.000009109156,0.0001376646,0.9961046,0.0002532679,0.000198624,0.002468636],"study_design_scores_gemma":[0.00004829264,0.0002740448,0.01655067,0.000012179,0.00004241347,0.0006127396,0.0000420987,0.002177713,0.9636491,0.000222968,0.01635676,0.00001108713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714447,0.01281429,0.007902512,0.0004267751,0.0001408661,0.0000725611,0.001176525,0.0004482756,0.005573427],"genre_scores_gemma":[0.9851767,0.003823988,0.0029745,0.0001274009,0.00002836272,0.00004616223,0.001988464,0.00003701172,0.005797262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001267042,"threshold_uncertainty_score":0.004238665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03381329294549038,"score_gpt":0.3339591659403426,"score_spread":0.3001458729948522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}