{"id":"W2133033875","doi":"10.1093/hmg/ddh197","title":"Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase","year":2004,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":241,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Cytochrome c oxidase; Biology; Phenotype; Mutant; Fusion protein; Electron Transport Complex IV; Transfection; Cell biology; Gene; Mitochondrion; Recombinant DNA; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001191142,0.000262499,0.0002191936,0.0001782738,0.0002130777,0.00005777034,0.0001650461,0.0002597611,0.00008020171],"category_scores_gemma":[0.00003549698,0.0002913836,0.0000734413,0.0001341416,0.0001376408,0.000004950529,0.0002086446,0.0001959944,0.00005853899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004455536,"about_ca_system_score_gemma":0.00008767297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006915112,"about_ca_topic_score_gemma":0.001585883,"domain_scores_codex":[0.9984406,0.0001118219,0.0003086652,0.0006291464,0.0001625409,0.0003471732],"domain_scores_gemma":[0.9991504,0.000003796662,0.00005661728,0.0004468642,0.0001286202,0.0002136886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003783151,0.0001031396,0.001320479,0.000008514758,0.00003178246,0.0000766956,0.0001549543,0.003239499,0.9938618,0.0005140204,0.0005822752,0.00006899018],"study_design_scores_gemma":[0.007709752,0.003993986,0.0725417,0.0001093192,0.0001107149,0.0002732718,0.0006717656,0.0000220931,0.897709,0.0009862146,0.01436081,0.00151142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914083,0.0006089663,0.005544501,0.00009711048,0.0001352424,0.0005020816,0.00002878191,0.00001706461,0.001657993],"genre_scores_gemma":[0.9962417,0.00003269482,0.001003233,0.001424509,0.0001532603,0.0000647069,0.0001700533,0.00004443302,0.0008654225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09615286,"threshold_uncertainty_score":0.9999538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578271029682269,"score_gpt":0.272532090471245,"score_spread":0.2567493801744223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}