{"id":"W2133088001","doi":"10.1111/tra.12046","title":"The Cytosolic Adaptor <scp>AP‐1A</scp> Is Essential for the Trafficking and Function of Niemann‐Pick Type C Proteins","year":2013,"lang":"en","type":"article","venue":"Traffic","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Montreal Heart Institute","funders":"National Center for Advancing Translational Sciences; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"NPC1; Signal transducing adaptor protein; Endosome; Cell biology; Biology; Cytosol; Clathrin; Intracellular; Endocytosis; Niemann–Pick disease; Secretion; Biochemistry; Cholesterol; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001422488,0.0003191135,0.000173491,0.0002117367,0.0004269296,0.0004706965,0.0002274668,0.000219762,0.001378756],"category_scores_gemma":[0.000204035,0.00009820404,0.0001748228,0.000195867,0.0002926778,0.0002287665,0.0003538702,0.0003940993,0.000904598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004852701,"about_ca_system_score_gemma":0.0004254192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001118324,"about_ca_topic_score_gemma":0.0009412671,"domain_scores_codex":[0.99988,0.00001993035,0.0000160205,0.00002131357,0.00004486561,0.00001799136],"domain_scores_gemma":[0.9998643,0.00001614107,0.00004553025,0.00001874156,0.00002451165,0.00003062598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001312643,0.00001349167,0.0003429974,0.00006048979,0.000006436456,0.0002814165,0.00001097976,0.00006708201,0.9957991,0.0004008105,0.0001437033,0.002742226],"study_design_scores_gemma":[0.00002344575,0.00007711592,0.01367467,0.0000227936,0.00003397791,0.003347046,0.00005540728,0.001898233,0.964305,0.0003876266,0.01616446,0.00001022834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826632,0.005881174,0.006956813,0.0003939418,0.00008390994,0.00002242474,0.0006731559,0.0003134441,0.003012102],"genre_scores_gemma":[0.9926421,0.00173656,0.001872994,0.00005388265,0.00001987309,0.00001366227,0.0009662398,0.00003287476,0.002661748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001378756,"threshold_uncertainty_score":0.004612386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02317253924362857,"score_gpt":0.2773706032351164,"score_spread":0.2541980639914879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}