{"id":"W2133090309","doi":"10.1016/j.virol.2011.01.026","title":"The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation","year":2011,"lang":"en","type":"article","venue":"Virology","topic":"Viral-associated cancers and disorders","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Cancer Institute, University of Pittsburgh; U.S. Public Health Service; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; National Cancer Institute; National Institutes of Health; Michael Smith Health Research BC","keywords":"Biology; Antigen processing; MHC class I; Antigen presentation; Major histocompatibility complex; Virology; Transporter associated with antigen processing; MHC restriction; Endoplasmic reticulum; Cytotoxic T cell; Cell biology; Antigen; Molecular biology; Immune system; T cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003145591,0.000288952,0.0002152394,0.0001538982,0.0002831352,0.0005409997,0.0004784088,0.000347287,0.001991258],"category_scores_gemma":[0.0003830706,0.0001835595,0.0002556494,0.00005895377,0.0004150625,0.000466215,0.0004240612,0.0008285799,0.001017983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006536953,"about_ca_system_score_gemma":0.0003375562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002729349,"about_ca_topic_score_gemma":0.0003625774,"domain_scores_codex":[0.999792,0.00005556354,0.00001187586,0.00003655502,0.00003821497,0.00006569514],"domain_scores_gemma":[0.9997217,0.00007817027,0.00007801923,0.00004394558,0.00002334253,0.00005473713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001898459,0.00002884474,0.0003433201,0.00004859218,0.000007630467,0.00006462273,0.00002641175,0.00007284511,0.9966658,0.0006478114,0.0001409079,0.001763409],"study_design_scores_gemma":[0.00001984141,0.0001478779,0.001674003,0.000009083436,0.00001127656,0.0005681071,0.00004867406,0.0007780659,0.9930627,0.0001967112,0.003478081,0.000005562684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991426,0.002442654,0.003335345,0.0002039404,0.0000560628,0.00001612566,0.00007838083,0.0001463185,0.002295196],"genre_scores_gemma":[0.9971063,0.0003010259,0.0009169199,0.0000750948,0.000008904416,0.000009315964,0.0001168513,0.00002503345,0.001440689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001991258,"threshold_uncertainty_score":0.006661475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801839687327814,"score_gpt":0.2525044451705123,"score_spread":0.2344860482972342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}