{"id":"W2133106296","doi":"10.1200/jco.2004.11.125","title":"Phase II Study of Activated Charcoal to Prevent Irinotecan-Induced Diarrhea","year":2004,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Irinotecan; Medicine; Diarrhea; Loperamide; Gastroenterology; Toxicity; Colorectal cancer; Internal medicine; Laxative; SN-38; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001286685,0.0001273514,0.0006946188,0.00007049611,0.00004357971,0.000004073321,0.0002877993,0.0002747547,0.00002096226],"category_scores_gemma":[0.0003763926,0.0001026923,0.0002686475,0.00009651254,0.00003645505,0.000004427835,0.0001436231,0.0003411076,0.000002031003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005526668,"about_ca_system_score_gemma":0.0009275671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003426911,"about_ca_topic_score_gemma":0.0001132899,"domain_scores_codex":[0.9978268,0.0001945348,0.00135304,0.0002093887,0.0002207274,0.000195524],"domain_scores_gemma":[0.9981846,0.00006163014,0.0009434659,0.0002451166,0.0002876525,0.0002775961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003089396,0.02193125,0.00003457365,0.00000447509,0.0003535266,0.00003511442,0.0002392646,0.0001150198,0.8700238,0.00004361587,0.0001054536,0.1040245],"study_design_scores_gemma":[0.01683932,0.2507689,0.0005356221,0.00002561822,0.0001281279,0.00003917341,0.0002425087,0.000001992531,0.6982533,0.0002587963,0.03277024,0.0001363804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996722,0.00008316002,0.0005156706,0.00122293,0.001017626,0.0002980272,0.000004967967,0.000002469123,0.0001331614],"genre_scores_gemma":[0.9975942,0.0001259199,0.0005342176,0.0008792254,0.0007768639,0.000007210033,0.000001969348,0.0000163356,0.00006410171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2288376,"threshold_uncertainty_score":0.418767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1127826133646169,"score_gpt":0.4780251388644942,"score_spread":0.3652425254998773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}