{"id":"W2133106296","doi":"10.1200/jco.2004.11.125","title":"Phase II Study of Activated Charcoal to Prevent Irinotecan-Induced Diarrhea","year":2004,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Irinotecan; Medicine; Diarrhea; Loperamide; Gastroenterology; Toxicity; Colorectal cancer; Internal medicine; Laxative; SN-38; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007867223,0.001042171,0.001669934,0.0003387987,0.0003100067,0.0005806567,0.0008197688,0.0008350429,0.002472325],"category_scores_gemma":[0.0005971267,0.0003574963,0.0006363728,0.0003322617,0.0007209617,0.0003885175,0.0001852847,0.00197732,0.0004513216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008432009,"about_ca_system_score_gemma":0.001883004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205714,"about_ca_topic_score_gemma":0.001806185,"domain_scores_codex":[0.9997202,0.0001315262,0.00001146615,0.00004389333,0.00003589836,0.00005705437],"domain_scores_gemma":[0.9995354,0.00007917613,0.00008936598,0.00005004146,0.00004590761,0.0002001807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5797384,0.1222843,0.004909142,0.000969094,0.001176519,0.0004672075,0.0003086533,0.003918551,0.1734169,0.0003722164,0.004079281,0.1083598],"study_design_scores_gemma":[0.361234,0.6100706,0.005085558,0.00003248451,0.0002782561,0.0003556303,0.00004704119,0.001752889,0.01808361,0.0001303127,0.002908156,0.00002146346],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947053,0.001643647,0.0006130018,0.0002116405,0.00008082245,0.001669936,0.0002411937,0.00007160015,0.0007628647],"genre_scores_gemma":[0.9923757,0.001486181,0.001574267,0.0003842861,0.0001008013,0.001232344,0.001006118,0.00002977496,0.001810554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002472325,"threshold_uncertainty_score":0.008270681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1127826133646169,"score_gpt":0.4780251388644942,"score_spread":0.3652425254998773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}