{"id":"W2133130307","doi":"10.1101/gad.211342.112","title":"The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation","year":2013,"lang":"en","type":"article","venue":"Genes & Development","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"BC Cancer Agency; National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; Rutgers Cancer Institute of New Jersey; University of Alberta; York University; Ministerio de Ciencia e Innovación; National Institute of General Medical Sciences; New York State Stem Cell Science","keywords":"SIRT2; Biology; Chromatin; Epigenetics; Mitosis; Acetylation; Genome instability; Cell biology; DNA methylation; Histone H4; Cell cycle; Cancer research; Genetics; Cell; DNA damage; Sirtuin; DNA; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008274889,0.0003245785,0.00022487,0.0002778916,0.0001700328,0.0002880767,0.0002056151,0.0002030992,0.001334221],"category_scores_gemma":[0.00009651633,0.0001265264,0.0002401425,0.0001567164,0.0001773637,0.0001461799,0.0002357354,0.0002529419,0.0003454498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002750857,"about_ca_system_score_gemma":0.0001494759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004555276,"about_ca_topic_score_gemma":0.001150522,"domain_scores_codex":[0.9999313,0.00001321751,0.000004226933,0.00001587286,0.00001843639,0.00001689116],"domain_scores_gemma":[0.9999341,0.000005730307,0.00002456379,0.000007668787,0.000009132655,0.00001879992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009913059,0.00001375465,0.0008521136,0.00003449992,0.00001584102,0.00004274635,0.00001117844,0.00007766948,0.9954327,0.0001787948,0.00006936195,0.003172273],"study_design_scores_gemma":[0.00002888811,0.0002699125,0.02969086,0.000007497211,0.00004254104,0.0003173663,0.00004126925,0.001371913,0.9615929,0.0002537309,0.006373044,0.00001017784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982553,0.00779494,0.005152976,0.0001900845,0.00006214697,0.0000172673,0.000453269,0.0002333541,0.003542928],"genre_scores_gemma":[0.9955676,0.001564132,0.000888132,0.00002963657,0.00001147047,0.000006002556,0.0003654773,0.00001427601,0.001553125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001334221,"threshold_uncertainty_score":0.004463434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008571348362643658,"score_gpt":0.2351463644305005,"score_spread":0.2265750160678569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}