{"id":"W2133130307","doi":"10.1101/gad.211342.112","title":"The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation","year":2013,"lang":"en","type":"article","venue":"Genes & Development","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":278,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"BC Cancer Agency; National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; Rutgers Cancer Institute of New Jersey; University of Alberta; York University; Ministerio de Ciencia e Innovación; National Institute of General Medical Sciences; New York State Stem Cell Science","keywords":"SIRT2; Biology; Chromatin; Epigenetics; Mitosis; Acetylation; Genome instability; Cell biology; DNA methylation; Histone H4; Cell cycle; Cancer research; Genetics; Cell; DNA damage; Sirtuin; DNA; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005090089,0.0001403373,0.0001982866,0.00002810095,0.0003445393,0.00003253846,0.00008484469,0.00005048307,0.00004015532],"category_scores_gemma":[0.00005047107,0.00006764584,0.00003345239,0.0001033568,0.0001372522,0.00005809969,0.00007359147,0.0001067242,0.000003924806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005264188,"about_ca_system_score_gemma":0.00006393987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003839082,"about_ca_topic_score_gemma":0.000005156292,"domain_scores_codex":[0.9986863,0.00009425195,0.0004168593,0.0002192036,0.0003611245,0.000222224],"domain_scores_gemma":[0.9991781,0.0001580563,0.0001685606,0.0002536241,0.0001593343,0.00008238597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005097374,0.00007548726,0.005940781,0.0001365531,0.00004437227,0.000001308397,0.001228052,0.00004741866,0.942822,0.000004777118,0.00009660301,0.0495517],"study_design_scores_gemma":[0.0006757468,0.0001325725,0.271356,0.00009258797,0.00005716799,0.00001459882,0.0007936775,0.003888312,0.7219547,0.0001061227,0.0008232953,0.000105186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899831,0.007357124,0.0002858074,0.001179786,0.0001019396,0.0009544663,0.000001537925,0.00002173131,0.0001145029],"genre_scores_gemma":[0.9943781,0.0001582011,0.005071001,0.00008395796,0.00007115802,0.0001021508,0.00003339441,0.00001497313,0.00008700885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2654153,"threshold_uncertainty_score":0.2758517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008571348362643658,"score_gpt":0.2351463644305005,"score_spread":0.2265750160678569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}