{"id":"W2133190342","doi":"10.1101/cshperspect.a008656","title":"Caspase Functions in Cell Death and Disease","year":2013,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2586,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research","funders":"","keywords":"Caspase; Biology; Proinflammatory cytokine; Cell biology; Apoptosis; Programmed cell death; Inflammation; Innate immune system; Signal transduction; Enzyme activator; Immunology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009011148,0.001242416,0.001579935,0.001830325,0.0006263613,0.001813712,0.001434942,0.001971488,0.004319443],"category_scores_gemma":[0.0006141113,0.0002630155,0.0004007197,0.002037083,0.001999751,0.002512302,0.001585069,0.003478846,0.005257173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001756473,"about_ca_system_score_gemma":0.001272896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006308447,"about_ca_topic_score_gemma":0.0009305395,"domain_scores_codex":[0.9996166,0.00005911167,0.00004018039,0.00007178014,0.0001634396,0.00004881005],"domain_scores_gemma":[0.9997081,0.0000688889,0.00003375426,0.00002149899,0.0001085473,0.00005916852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001019448,0.00006064436,0.0001468418,0.005700217,0.00004438783,0.0003462464,0.0001476355,0.0004060823,0.006380608,0.03724581,0.09028682,0.8591327],"study_design_scores_gemma":[0.00001051313,0.00002913205,0.0001993704,0.000602778,0.00001053129,0.0006421519,0.0000311115,0.00003546954,0.0005817842,0.006515786,0.9913322,0.000009281717],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009388915,0.9955884,0.0002893689,0.0006036826,0.0007745264,0.000004960402,0.00001370526,0.00001537682,0.002616061],"genre_scores_gemma":[0.001530546,0.9941065,0.0003737309,0.0005804281,0.0006697591,0.00001352491,0.00003615216,0.000004831735,0.002684477],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004319443,"threshold_uncertainty_score":0.01444995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02374702479029986,"score_gpt":0.2955320845366302,"score_spread":0.2717850597463303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}