{"id":"W2133215208","doi":"10.1091/mbc.e09-11-0947","title":"TBC-2 Regulates RAB-5/RAB-7-mediated Endosomal Trafficking in<i>Caenorhabditis elegans</i>","year":2010,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Rutgers, The State University of New Jersey","keywords":"Rab; Endosome; Cell biology; Biology; GTPase; Caenorhabditis elegans; Small GTPase; Guanine nucleotide exchange factor; Transport protein; Lysosome; GTPase-activating protein; Biochemistry; Signal transduction; G protein; Intracellular","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533648,0.0002312179,0.0002521104,0.00007354873,0.00006681294,0.000008574983,0.0004923011,0.0004691235,0.00004679634],"category_scores_gemma":[0.00006071675,0.0001911663,0.0002513758,0.0001737117,0.0003311524,0.000003588294,0.00009490715,0.0003358522,0.000007159872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007425381,"about_ca_system_score_gemma":0.00007248746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005570912,"about_ca_topic_score_gemma":0.0002264474,"domain_scores_codex":[0.9986006,0.0001264459,0.0003618107,0.0004301074,0.0001116752,0.0003693801],"domain_scores_gemma":[0.9990953,0.00002029903,0.0001586509,0.0005951207,0.0000622612,0.00006837075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005534567,0.00009243375,0.01141298,0.00001962994,0.00002613765,0.00001038142,0.00005065353,0.00004799665,0.9878091,0.0001469226,0.0000335085,0.0002948998],"study_design_scores_gemma":[0.0008801722,0.0001350252,0.006354289,0.00001195768,0.0000270837,0.00001770709,0.00002049081,0.00006105663,0.9765658,0.000210434,0.01550642,0.0002095142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954605,0.001050379,0.001498478,0.000229397,0.0004951157,0.0002601361,0.00003312465,0.00001602339,0.0009568327],"genre_scores_gemma":[0.9977461,0.00008368287,0.000411973,0.0002507109,0.00009634049,0.00001392683,0.001168681,0.00003322702,0.0001954364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01547291,"threshold_uncertainty_score":0.7795534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002720942974080453,"score_gpt":0.1923184138270328,"score_spread":0.1895974708529524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}