{"id":"W2133225290","doi":"10.1210/en.2005-0600","title":"Organ Messenger Ribonucleic Acid and Plasma Proteome Changes in the Adjuvant-Induced Arthritis Model: Responses to Disease Induction and Therapy with the Estrogen Receptor-β Selective Agonist ERB-041","year":2005,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada)","funders":"","keywords":"Endocrinology; Internal medicine; Agonist; Estrogen; Estrogen receptor; Medicine; Arthritis; Adjuvant; Disease; Messenger RNA; Receptor; Biology; Cancer; Breast cancer; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376965,0.0003317619,0.0003492579,0.0004814831,0.0001607646,0.0002310262,0.0001035066,0.0002400251,0.001032607],"category_scores_gemma":[0.0001324624,0.0001519319,0.0001931666,0.0002913437,0.0002372273,0.0001364505,0.0001048702,0.0004517296,0.0003210206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001716083,"about_ca_system_score_gemma":0.0001267631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003039988,"about_ca_topic_score_gemma":0.0004460725,"domain_scores_codex":[0.9998819,0.00002164603,0.000006598338,0.00002986403,0.00002934991,0.00003067636],"domain_scores_gemma":[0.9998648,0.00002019332,0.00003889596,0.00001406596,0.00001616982,0.00004586086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005590126,0.00003101864,0.000310072,0.00001649725,0.000007604097,0.00004655982,0.000009539485,0.0000202444,0.9982487,0.00001716608,0.00002045328,0.0007131048],"study_design_scores_gemma":[0.00007119483,0.00172495,0.05926234,0.000007091283,0.00008761015,0.0008123528,0.0000929033,0.0006941222,0.9355022,0.000140309,0.001588634,0.0000162712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951839,0.001778976,0.001362435,0.00006349108,0.00002945429,0.00001854839,0.0007959545,0.00004926263,0.0007180026],"genre_scores_gemma":[0.9920028,0.001396588,0.00207065,0.00007829641,0.00002264191,0.00006808584,0.001333448,0.00002419817,0.003003374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001032607,"threshold_uncertainty_score":0.003454447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009825895242711756,"score_gpt":0.2383404922002865,"score_spread":0.2285145969575748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}