{"id":"W2133225290","doi":"10.1210/en.2005-0600","title":"Organ Messenger Ribonucleic Acid and Plasma Proteome Changes in the Adjuvant-Induced Arthritis Model: Responses to Disease Induction and Therapy with the Estrogen Receptor-β Selective Agonist ERB-041","year":2005,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada)","funders":"","keywords":"Endocrinology; Internal medicine; Agonist; Estrogen; Estrogen receptor; Medicine; Arthritis; Adjuvant; Disease; Messenger RNA; Receptor; Biology; Cancer; Breast cancer; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001251524,0.0002045725,0.0001607028,0.00007066005,0.0002017999,0.00003437364,0.0001437557,0.0001210826,0.000003825348],"category_scores_gemma":[0.00004464375,0.0001211195,0.0000235845,0.0001382575,0.000176521,0.000009409687,0.0000721267,0.0002726287,0.000004163069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001532586,"about_ca_system_score_gemma":0.00007263456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001760851,"about_ca_topic_score_gemma":0.0001542899,"domain_scores_codex":[0.9987552,0.0002809219,0.0001077983,0.0003998158,0.00009562736,0.0003606708],"domain_scores_gemma":[0.9995281,0.00003256147,0.00005264325,0.0002554967,0.00004052772,0.00009064314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001758071,0.00007486006,0.001141726,0.000004715297,0.00007930194,0.00002497091,0.0009627077,0.00005328191,0.9657754,0.0001068491,0.0003342176,0.02968396],"study_design_scores_gemma":[0.001993692,0.002067401,0.008586156,0.00002225535,0.00003002586,0.0004246311,0.000581876,0.0001345284,0.9776931,0.00004167442,0.008099561,0.0003251421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820794,0.005029172,0.0000157562,0.01198549,0.00003199187,0.0007860102,0.00001553591,0.00001756955,0.00003900587],"genre_scores_gemma":[0.9956535,0.003036331,0.0001872468,0.0005554668,0.0001523606,0.0002821939,0.00002281916,0.00002734108,0.00008270319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02935882,"threshold_uncertainty_score":0.4939109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009825895242711756,"score_gpt":0.2383404922002865,"score_spread":0.2285145969575748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}