{"id":"W2133243301","doi":"10.1016/j.nbd.2011.03.018","title":"Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease","year":2011,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":75,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"White matter; Corpus callosum; Pathology; Huntington's disease; Globus pallidus; Atrophy; Biology; Neuroscience; Magnetic resonance imaging; Thalamus; Anatomy; Medicine; Central nervous system; Basal ganglia; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002662333,0.0003741096,0.0005764809,0.0003902811,0.00003452123,0.000003695986,0.001050024,0.00008995605,0.00008727223],"category_scores_gemma":[0.002334301,0.0002940338,0.0003008917,0.0003976258,0.001471975,0.0001331954,0.0002426582,0.0004129883,0.000004659079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000481834,"about_ca_system_score_gemma":0.0004133988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003348239,"about_ca_topic_score_gemma":0.00001624791,"domain_scores_codex":[0.9953723,0.002075019,0.0008485204,0.000895235,0.0003028344,0.0005061086],"domain_scores_gemma":[0.9974245,0.0005352335,0.0005635313,0.001050496,0.00009489762,0.0003313214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004476596,0.001841857,0.2118918,0.0004202264,0.000007535806,0.0001190946,0.001275562,0.0001951477,0.7777796,0.001428371,0.0004886696,0.00007550593],"study_design_scores_gemma":[0.001314576,0.0003222838,0.8477514,0.0000978853,0.0001190114,5.110396e-7,0.00006206611,0.00006927395,0.1484731,0.001411302,0.00005165237,0.0003268856],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970531,0.0007031251,0.000003722788,0.0002613728,0.0004117184,0.0008146763,0.0005776855,0.00002448263,0.000150044],"genre_scores_gemma":[0.9980918,0.0001081811,0.00003079336,0.001394111,0.00002764173,0.0000948044,0.00003521066,0.00003768238,0.0001798256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6358596,"threshold_uncertainty_score":0.9999512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02580010795410234,"score_gpt":0.2442624669699764,"score_spread":0.2184623590158741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}