{"id":"W2133268278","doi":"10.1093/hmg/ddt071","title":"Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Istituto Italiano di Tecnologia; Ministero della Salute; European Commission; Compagnia di San Paolo; Brown University","keywords":"Excitatory postsynaptic potential; Biology; Neuroscience; Inhibitory postsynaptic potential; Neurotransmission; Synaptic plasticity; Excitatory synapse; Epileptogenesis; Synapsin; Neural facilitation; Synaptic vesicle; Hippocampal formation; Genetics; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183761,0.0002384912,0.0002423456,0.0002366203,0.0002310285,0.0001409306,0.000511406,0.00009223929,0.0001076122],"category_scores_gemma":[0.0001974455,0.0002339661,0.00006215331,0.0004217573,0.000657599,0.0001188004,0.0002652182,0.0004273385,0.00006354052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005283845,"about_ca_system_score_gemma":0.00006105591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001234653,"about_ca_topic_score_gemma":0.00002000244,"domain_scores_codex":[0.9974777,0.0003029471,0.0003344234,0.0007836075,0.000429052,0.0006723464],"domain_scores_gemma":[0.9991834,0.0001680572,0.0000594548,0.0002859202,0.00003816086,0.0002650094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000145719,0.0001047012,0.008736935,0.00001754036,0.000002198388,0.0006160485,0.00004020422,0.0001074698,0.9888462,0.0003278949,0.00002599019,0.001160208],"study_design_scores_gemma":[0.0006002483,0.0003513873,0.05810547,0.00001544422,0.00001578978,0.0001009264,0.00001846833,0.01973508,0.9200767,0.0006375824,0.00002868453,0.000314163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984686,0.00009977546,0.0001319104,0.0001255793,0.0001336926,0.0005844316,0.00001279474,0.00004534574,0.0003979118],"genre_scores_gemma":[0.9984583,0.0005299642,0.00002927701,0.0007584555,0.00002571031,0.00006146015,0.000001260543,0.00003457279,0.0001010252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06876948,"threshold_uncertainty_score":0.9540859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03068295393164138,"score_gpt":0.3148854637562601,"score_spread":0.2842025098246188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}