{"id":"W2133308819","doi":"10.1073/pnas.1008937107","title":"Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2)","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":219,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; Western University; Lunenfeld-Tanenbaum Research Institute; Structural Genomics Consortium; University of Toronto","funders":"National Institute of General Medical Sciences; Ontario Genomics; National Institutes of Health; Knut och Alice Wallenbergs Stiftelse; Karolinska Institutet; Stiftelsen för Strategisk Forskning; Ontario Genomics Institute; Canadian Institutes of Health Research; Genome Canada; GlaxoSmithKline; Ontario Innovation Trust; Wellcome Trust","keywords":"PRC2; Histone methyltransferase; EZH2; Histone; Histone H3; Histone methylation; Histone H2A; Biochemistry; Chemistry; Methylation; Biology; Cell biology; DNA; DNA methylation; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001024655,0.0001753307,0.0002078589,0.00008230033,0.0001598516,0.0003630437,0.0001562239,0.0001609227,0.001302974],"category_scores_gemma":[0.0001297554,0.0001452904,0.0002522779,0.0001191296,0.0002012116,0.0001396623,0.0003576731,0.0003269528,0.000398484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003066465,"about_ca_system_score_gemma":0.0001164216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007442219,"about_ca_topic_score_gemma":0.001222392,"domain_scores_codex":[0.9997914,0.00001977697,0.00001558605,0.00007335139,0.00005210309,0.00004779853],"domain_scores_gemma":[0.9999373,0.000008768095,0.00001736005,0.000007936596,0.00001003911,0.00001856735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006251798,0.000007574201,0.0008586448,0.00002710008,0.000007400044,0.00003578654,0.00001199948,0.00006671183,0.9975685,0.00008000863,0.00005409779,0.001219621],"study_design_scores_gemma":[0.00001468595,0.00005758583,0.03404894,0.000003520724,0.00001292424,0.0002545489,0.00003776657,0.001678615,0.9600841,0.00006572973,0.003732568,0.000009017394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932275,0.002245791,0.002670863,0.00007211598,0.00002887112,0.000006337916,0.0002314338,0.00007041398,0.001446664],"genre_scores_gemma":[0.9972217,0.0003797603,0.0007270359,0.00005615468,0.00000443779,0.00000633451,0.0002671448,0.00001094231,0.001326517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001302974,"threshold_uncertainty_score":0.004358947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02861385412375547,"score_gpt":0.3037507229615256,"score_spread":0.2751368688377701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}