{"id":"W2133312268","doi":"10.1158/1078-0432.ccr-06-1651","title":"Flaxseed and Its Lignans Inhibit Estradiol-Induced Growth, Angiogenesis, and Secretion of Vascular Endothelial Growth Factor in Human Breast Cancer Xenografts <i>In vivo</i>","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Phytoestrogen effects and research","field":"Medicine","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Enterolactone; Phytoestrogens; Angiogenesis; Endocrinology; Internal medicine; Vascular endothelial growth factor; In vivo; Biology; Kinase insert domain receptor; Estrogen receptor; Breast cancer; Medicine; Cancer research; Vascular endothelial growth factor A; Cancer; Estrogen; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001007212,0.000407042,0.0002600168,0.0002098627,0.00009050537,0.0001310373,0.0001313091,0.0001931684,0.0008836136],"category_scores_gemma":[0.0000905734,0.00009697511,0.000281858,0.0001532461,0.0001240328,0.0001377326,0.0000943016,0.0003442557,0.0001954099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000172172,"about_ca_system_score_gemma":0.0001650722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001092441,"about_ca_topic_score_gemma":0.001649545,"domain_scores_codex":[0.9999479,0.00001060171,0.000004968515,0.000008655736,0.00001239324,0.000015402],"domain_scores_gemma":[0.9999472,0.00001242743,0.00001544199,0.000004375264,0.000006009055,0.00001455689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001069802,0.0002714128,0.0002179987,0.00007087346,0.00001648499,0.00002945825,0.00001460654,0.00006558462,0.9955007,0.00002402607,0.00008512467,0.002633825],"study_design_scores_gemma":[0.0001159575,0.004257475,0.004644999,0.000009373733,0.00005082434,0.0001535972,0.0000224431,0.0006133925,0.9880155,0.00001657516,0.002094247,0.000005523149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949369,0.002835153,0.0007173929,0.00009185632,0.00003050658,0.00003180452,0.0002687418,0.00007574842,0.001011982],"genre_scores_gemma":[0.9932109,0.002231415,0.001378838,0.00008324935,0.00001632853,0.00005024829,0.0008507522,0.00001583985,0.002162504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001092441,"threshold_uncertainty_score":0.002955973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09553616797418367,"score_gpt":0.4469377798305834,"score_spread":0.3514016118563997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}