{"id":"W2133312268","doi":"10.1158/1078-0432.ccr-06-1651","title":"Flaxseed and Its Lignans Inhibit Estradiol-Induced Growth, Angiogenesis, and Secretion of Vascular Endothelial Growth Factor in Human Breast Cancer Xenografts <i>In vivo</i>","year":2007,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Phytoestrogen effects and research","field":"Medicine","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Enterolactone; Phytoestrogens; Angiogenesis; Endocrinology; Internal medicine; Vascular endothelial growth factor; In vivo; Biology; Kinase insert domain receptor; Estrogen receptor; Breast cancer; Medicine; Cancer research; Vascular endothelial growth factor A; Cancer; Estrogen; VEGF receptors","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004546949,0.0002328186,0.0007522733,0.0006636033,0.000119523,0.00002951206,0.0001906808,0.0003715863,0.000120984],"category_scores_gemma":[0.0004862156,0.0001893645,0.0001687203,0.001007328,0.000478227,0.0001306283,0.0001696991,0.001111447,0.000001980489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002286834,"about_ca_system_score_gemma":0.0005215501,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007514304,"about_ca_topic_score_gemma":0.003299856,"domain_scores_codex":[0.9959198,0.0005488988,0.0008400106,0.000719459,0.001030182,0.0009416228],"domain_scores_gemma":[0.9976429,0.0009025374,0.00009578453,0.0002630899,0.0005136741,0.0005820204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009993328,0.0003896295,0.5085033,0.0005575488,0.0000830553,0.0001499715,0.0001948396,5.460048e-7,0.4847476,0.0001189489,0.00005224968,0.004202987],"study_design_scores_gemma":[0.00542704,0.001027598,0.7785692,0.0008769062,0.00003377858,0.00002582065,0.00009558024,0.00008924943,0.2134527,0.00009333701,0.0001050844,0.0002037308],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936584,0.003804868,0.000003184771,0.0008548258,0.0001329615,0.001218254,0.0001445634,0.00001772071,0.0001651971],"genre_scores_gemma":[0.9925803,0.00644504,0.0000180376,0.00007000725,0.0006585913,0.0001071528,0.000007525934,0.00004635061,0.00006700998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2712949,"threshold_uncertainty_score":0.9990947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09553616797418367,"score_gpt":0.4469377798305834,"score_spread":0.3514016118563997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}