{"id":"W2133349572","doi":"10.1002/humu.22025","title":"Ovarian cancer susceptibility alleles and risk of ovarian cancer in<i>BRCA1</i>and<i>BRCA2</i>mutation carriers","year":2012,"lang":"en","type":"article","venue":"Human Mutation","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Université Laval; Centre hospitalier universitaire de Québec","funders":"Medical Research Council; Cancer Center, University of Kansas; National Institutes of Health; Istituto Oncologico Veneto; Fondazione Italiana per la Ricerca sul Cancro; Cancer Council Victoria; Deutsche Krebshilfe; Sahlgrenska Universitetssjukhuset; Umeå Universitet; National Cancer Institute; Landspítali Háskólasjúkrahús; Istituto Toscano Tumori; Hungarian Scientific Research Fund; Canadian Institutes of Health Research; University of California, Los Angeles; Cancerfonden; Lunds Universitet; ZonMw; National Breast Cancer Foundation; National Institute for Health and Care Research; Linköpings Universitet; Canadian Breast Cancer Research Alliance; Royal Marsden NHS Foundation Trust; Ovarian Cancer Research Fund; Huntsman Cancer Institute; Deutsches Krebsforschungszentrum; Helsingin ja Uudenmaan Sairaanhoitopiiri; University of California, San Francisco; Ministero della Salute; Akademiska Sjukhuset; Cancer Care Ontario; Cancer Research UK; Beckman Research Institute, City of Hope; Fox Chase Cancer Center; Alleanza Contro il Cancro; Uppsala Universitet; Ministero dell’Istruzione, dell’Università e della Ricerca; Memorial Sloan-Kettering Cancer Center; Instituto de Salud Carlos III; Ohio State University; National Health and Medical Research Council; Kansas Bioscience Authority; University of Pennsylvania; Russian Foundation for Basic Research; Georgetown University; Breast Cancer Research Foundation; U.S. Department of Defense","keywords":"Ovarian cancer; Biology; Odds ratio; Single-nucleotide polymorphism; Breast cancer; Hazard ratio; Oncology; Allele; Internal medicine; Population; Genome-wide association study; Cancer; Genetics; Gynecology; Genotype; Medicine; Confidence interval; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004651821,0.0001779531,0.0001863499,0.00009941912,0.0001386377,0.00002331747,0.00008200287,0.0001727576,0.00008833874],"category_scores_gemma":[0.00008616718,0.0001906782,0.00004331512,0.0001439355,0.0001955573,0.00003228995,0.00005476195,0.0001233153,9.847614e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001406393,"about_ca_system_score_gemma":0.0001496103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002615212,"about_ca_topic_score_gemma":0.008836194,"domain_scores_codex":[0.9986914,0.0001646263,0.0003476583,0.0003771201,0.0001544941,0.0002647415],"domain_scores_gemma":[0.999256,0.00002505876,0.0002405228,0.0002433288,0.0001372724,0.0000978854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001529383,0.0001055199,0.7016164,0.0001652008,0.000287317,0.000001760453,0.008106099,0.002740468,0.2508724,0.0006954572,0.000316216,0.03494027],"study_design_scores_gemma":[0.001634322,0.000115945,0.9375287,0.0000390516,0.0001440619,0.00000903045,0.001036103,0.0003340072,0.05698463,0.0007937555,0.001071104,0.0003092691],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939256,0.004309581,0.0007514615,0.0001168976,0.0002141062,0.0003342124,0.0001226306,0.00001248942,0.0002129992],"genre_scores_gemma":[0.9974858,0.0009314751,0.0008672915,0.00007151549,0.0002522256,0.0001452239,0.0001432366,0.00002866679,0.00007461345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2359123,"threshold_uncertainty_score":0.777563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440082730073745,"score_gpt":0.2935355259518974,"score_spread":0.27913469865116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}