{"id":"W2133349572","doi":"10.1002/humu.22025","title":"Ovarian cancer susceptibility alleles and risk of ovarian cancer in<i>BRCA1</i>and<i>BRCA2</i>mutation carriers","year":2012,"lang":"en","type":"article","venue":"Human Mutation","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cancer Care Ontario; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Université Laval; Centre hospitalier universitaire de Québec","funders":"Medical Research Council; Cancer Center, University of Kansas; National Institutes of Health; Istituto Oncologico Veneto; Fondazione Italiana per la Ricerca sul Cancro; Cancer Council Victoria; Deutsche Krebshilfe; Sahlgrenska Universitetssjukhuset; Umeå Universitet; National Cancer Institute; Landspítali Háskólasjúkrahús; Istituto Toscano Tumori; Hungarian Scientific Research Fund; Canadian Institutes of Health Research; University of California, Los Angeles; Cancerfonden; Lunds Universitet; ZonMw; National Breast Cancer Foundation; National Institute for Health and Care Research; Linköpings Universitet; Canadian Breast Cancer Research Alliance; Royal Marsden NHS Foundation Trust; Ovarian Cancer Research Fund; Huntsman Cancer Institute; Deutsches Krebsforschungszentrum; Helsingin ja Uudenmaan Sairaanhoitopiiri; University of California, San Francisco; Ministero della Salute; Akademiska Sjukhuset; Cancer Care Ontario; Cancer Research UK; Beckman Research Institute, City of Hope; Fox Chase Cancer Center; Alleanza Contro il Cancro; Uppsala Universitet; Ministero dell’Istruzione, dell’Università e della Ricerca; Memorial Sloan-Kettering Cancer Center; Instituto de Salud Carlos III; Ohio State University; National Health and Medical Research Council; Kansas Bioscience Authority; University of Pennsylvania; Russian Foundation for Basic Research; Georgetown University; Breast Cancer Research Foundation; U.S. Department of Defense","keywords":"Ovarian cancer; Biology; Odds ratio; Single-nucleotide polymorphism; Breast cancer; Hazard ratio; Oncology; Allele; Internal medicine; Population; Genome-wide association study; Cancer; Genetics; Gynecology; Genotype; Medicine; Confidence interval; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004949749,0.0002931187,0.0002656463,0.0006348043,0.0002710812,0.0004951427,0.0002874638,0.0005803586,0.0018186],"category_scores_gemma":[0.00217853,0.0002754765,0.0006150529,0.0006316153,0.0003328514,0.0001893184,0.0003342289,0.0004577521,0.0001774287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001674368,"about_ca_system_score_gemma":0.0001529093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00264017,"about_ca_topic_score_gemma":0.002912783,"domain_scores_codex":[0.9997281,0.00006296252,0.00002523902,0.0001074887,0.00003611395,0.00003998974],"domain_scores_gemma":[0.9988616,0.0002651776,0.0005984578,0.0001080315,0.00004751317,0.0001192361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007769914,0.00003712545,0.9921292,0.00001641558,0.000199293,0.000219642,0.00005721084,0.00009708864,0.003236912,0.00005483761,0.0001421315,0.003033145],"study_design_scores_gemma":[0.00005820742,0.0001529403,0.9975383,0.000007112334,0.0002000143,0.0009011232,0.00004988316,0.0002854795,0.0003431946,0.0001464545,0.0003123159,0.000005116313],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990197,0.0004214734,0.00009487174,0.00004836364,0.000006327868,0.000003774178,0.0001760272,0.000006717396,0.0002226504],"genre_scores_gemma":[0.9992494,0.000173622,0.0001096925,0.00003165615,0.00001461921,0.000004703311,0.0001906803,0.000004248156,0.0002212933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00264017,"threshold_uncertainty_score":0.006083786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440082730073745,"score_gpt":0.2935355259518974,"score_spread":0.27913469865116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}