{"id":"W2133352477","doi":"10.1124/jpet.105.086363","title":"Lecozotan (SRA-333): A Selective Serotonin 1A Receptor Antagonist That Enhances the Stimulated Release of Glutamate and Acetylcholine in the Hippocampus and Possesses Cognitive-Enhancing Properties","year":2005,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Microdialysis; Agonist; Pharmacology; Chemistry; Receptor antagonist; NMDA receptor; Acetylcholine; Serotonin; 5-HT receptor; Dentate gyrus; Antagonist; Endocrinology; Internal medicine; Receptor; Hippocampal formation; Medicine; Extracellular; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006284246,0.000191086,0.0002819135,0.0001241775,0.0004185,0.00007221976,0.000279048,0.00006571221,0.00002791722],"category_scores_gemma":[0.0000483582,0.0001092555,0.00003845045,0.00027604,0.001418328,0.0004116872,0.0001073617,0.0006184679,0.000001146815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003068212,"about_ca_system_score_gemma":0.0001058002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004171963,"about_ca_topic_score_gemma":0.000003173195,"domain_scores_codex":[0.9978933,0.0008885525,0.000371223,0.0002629223,0.0002636962,0.0003202871],"domain_scores_gemma":[0.9987416,0.0007721867,0.0002885615,0.00005783414,0.00007136683,0.00006841605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002528706,0.0003619392,0.0005236402,0.0000199678,0.00003075782,0.00005011095,0.004771979,0.00001776517,0.9896278,0.000005944285,0.00003308761,0.00202828],"study_design_scores_gemma":[0.002200911,0.001221587,0.0004080694,0.00003801865,0.00005913144,0.000786636,0.002375087,0.0006400088,0.9918859,0.00004180575,0.0002322331,0.0001105976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913756,0.004629274,0.000003013786,0.003273074,0.0002063121,0.0004786724,0.000006809711,0.000007327364,0.00001996708],"genre_scores_gemma":[0.9866654,0.007489293,0.00001556709,0.005688241,0.00008934054,0.00001961248,1.205469e-7,0.00001328318,0.00001917433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004710183,"threshold_uncertainty_score":0.5225889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06099259732688803,"score_gpt":0.3782218026996326,"score_spread":0.3172292053727445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}