{"id":"W2133352477","doi":"10.1124/jpet.105.086363","title":"Lecozotan (SRA-333): A Selective Serotonin 1A Receptor Antagonist That Enhances the Stimulated Release of Glutamate and Acetylcholine in the Hippocampus and Possesses Cognitive-Enhancing Properties","year":2005,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Microdialysis; Agonist; Pharmacology; Chemistry; Receptor antagonist; NMDA receptor; Acetylcholine; Serotonin; 5-HT receptor; Dentate gyrus; Antagonist; Endocrinology; Internal medicine; Receptor; Hippocampal formation; Medicine; Extracellular; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006745837,0.0004218276,0.0003798717,0.0002812173,0.0001526649,0.0001926115,0.0002939308,0.0002896183,0.001904734],"category_scores_gemma":[0.00009867715,0.0001285594,0.0001986401,0.0002084814,0.0002533771,0.0003033737,0.0001222998,0.0007073962,0.000622245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000244081,"about_ca_system_score_gemma":0.0004148922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001445694,"about_ca_topic_score_gemma":0.003620044,"domain_scores_codex":[0.9999655,0.000005276454,0.000002643706,0.000004636655,0.000008169878,0.00001368352],"domain_scores_gemma":[0.9999555,0.000005475529,0.00001252439,0.000003172803,0.00000454816,0.00001882089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002359907,0.0004000824,0.0006298052,0.0003434079,0.00004510419,0.0004704388,0.00003002041,0.0002416129,0.9609243,0.0006340593,0.0007852882,0.03313603],"study_design_scores_gemma":[0.001381006,0.007688179,0.01067024,0.00002525486,0.0002003501,0.002037807,0.00005239321,0.001360025,0.9686878,0.0001518364,0.007710254,0.0000348561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889515,0.003685759,0.002162161,0.0002521905,0.00004864524,0.00009006324,0.0004946747,0.0003883009,0.003926639],"genre_scores_gemma":[0.9910225,0.003965785,0.001929139,0.0001135614,0.00002505833,0.00003841015,0.0007223636,0.00001970059,0.002163525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001904734,"threshold_uncertainty_score":0.006371915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06099259732688803,"score_gpt":0.3782218026996326,"score_spread":0.3172292053727445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}